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Durability assessment of hydrogel mountings for contrast-enhanced micro-CT.
Hildebrand, Torben; Novak, Jan; Nogueira, Liebert Parreiras; Boccaccini, Aldo Roberto; Haugen, Håvard Jostein.
Afiliación
  • Hildebrand T; Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo 0317, Norway. Electronic address: torbehil@odont.uio.no.
  • Novak J; Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo 0317, Norway; Department of Materials Science and Engineering, Friedrich-Alexander-Universität, 91054 Erlangen, Germany.
  • Nogueira LP; Oral Research Laboratory, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo 0317, Norway.
  • Boccaccini AR; Department of Materials Science and Engineering, Friedrich-Alexander-Universität, 91054 Erlangen, Germany.
  • Haugen HJ; Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo 0317, Norway.
Micron ; 174: 103533, 2023 11.
Article en En | MEDLINE | ID: mdl-37660476
Micro-computed tomography (micro-CT) provides valuable data for studying soft tissue, though it is often affected by sample movement during scans and low contrast in X-ray absorption. This can result in lower image quality and geometric inaccuracies, collectively known as 'artefacts'. To mitigate these issues, samples can be embedded in hydrogels and enriched with heavy metals for contrast enhancement. However, the long-term durability of these enhancements remains largely unexplored. In this study, we examine the effects of two contrast enhancement agents - iodine and phosphotungstic acid (PTA) - and two hydrogels - agarose and Poloxamer 407 - over a 14-day period. We used Drosophila melanogaster as a test model for our investigation. Our findings reveal that PTA and agarose are highly durable, while iodine and poloxamer hydrogel exhibits higher leakage rates. These observations lay the foundation for estimating contrast stabilities in contrast-enhanced micro-CT with hydrogel embedding and serve to inform future research in this field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Yodo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Micron Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Yodo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Micron Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido