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Angiopoietin4 (ANGPT4) expression and potential mechanisms in carcinogenesis: current achievements and perspectives.
Zhou, Wen-Chao; Zhang, Qun-Feng; Chen, Jun-Ling; Gan, Jin-Peng; Li, Yu-Kun; Zou, Juan.
Afiliación
  • Zhou WC; Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
  • Zhang QF; Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
  • Chen JL; Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
  • Gan JP; Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
  • Li YK; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. yukun_li@foxmail.com.
  • Zou J; Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China. zoujuanusc@usc.edu.cn.
Clin Exp Med ; 23(8): 4449-4456, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37659993
Angiopoietin4(ANGPT4) which plays a significant role in endothelial cell proliferation, survival, angiogenesis and expansion in tumors and other pathological states is a significant regulator of tumor angiogenesis. ANGPT4 expression is enhanced in many cancer cells. For example, the overexpression of ANGPT4 promotes the formation, development and progress of lung adenocarcinoma, glioblastoma and ovarian cancer. Related studies show that ANGPT4 encourages the proliferation, survival and invasion of tumor cells, while promoting the expansion of the tumor vascular system and affecting the tumor immune microenvironment. ANGPT4 can also promote carcinogenesis by affecting the ERK1/2, PI3K/AKT and other signal pathways downstream of tyrosine kinase with immunoglobulin-like and EGF-like domains 2(TIE2) and TIE2. Therefore, ANGPT4 may be a potential and significant biomarker for predicting malignant tumor progression and adverse outcomes. In addition, inhibition of ANGPT4 may be a meaningful cancer treatment. This paper reviews the latest research results of ANGPT4 in preclinical research, and emphasizes its role in carcinogenesis. Additional research on the carcinogenic function of ANGPT4 could provide new insights into cancer biology and novel methods for cancer diagnosis and treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Clin Exp Med Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Clin Exp Med Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia