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Identifying Mediators of Intervention Effects Within a Randomized Controlled Trial to Motivate Cancer Genetic Risk Assessment Among Breast and Ovarian Cancer Survivors.
An, Jinghua; Lu, Shou-En; McDougall, Jean; Walters, Scott T; Lin, Yong; Heidt, Emily; Stroup, Antoinette; Paddock, Lisa; Grumet, Sherry; Toppmeyer, Deborah; Kinney, Anita Y.
Afiliación
  • An J; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Lu SE; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • McDougall J; School of Public Health, The State University of New Jersey, New Brunswick, NJ, USA.
  • Walters ST; Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Lin Y; University of North Texas Health Science Center, Fort Worth, TX, USA.
  • Heidt E; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Stroup A; School of Public Health, The State University of New Jersey, New Brunswick, NJ, USA.
  • Paddock L; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Grumet S; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Toppmeyer D; School of Public Health, The State University of New Jersey, New Brunswick, NJ, USA.
  • Kinney AY; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Ann Behav Med ; 57(11): 965-977, 2023 10 16.
Article en En | MEDLINE | ID: mdl-37658805
It is recommended that cancer survivors at increased risk for heredity seek cancer genetic risk assessment (CGRA), which includes cancer genetic counseling and genetic testing. A Tailored Counseling and Navigation (TCN) intervention successfully increased CGRA uptake among women with a history of cancer who enrolled in a randomized controlled trial. Understanding reasons for TCN's effectiveness can guide future interventions that use risk messages and behavior change techniques. We conducted mediation analyses, which enabled identification of the TCN's active components. Eligible breast and ovarian cancer survivors (n = 641) were recruited from three statewide cancer registries and were assigned to three groups: TCN, Targeted Print, and Usual Care. Mediator variables drawn from behavioral and risk communication theories were assessed at baseline and 1-month follow-up; CGRA uptake was assessed at 6 months. The strongest mediator was intention to obtain a CGRA, followed by self-efficacy, perceived risk, knowledge of hereditary breast and ovarian cancer, and perceived CGRA benefits. Risk communication and behavioral change interventions for hereditary cancer should stress a person's increased genetic risk and the potential benefits of genetic counseling and testing, as well as bolster efficacy beliefs by helping remove CGRA barriers. System-level and policy interventions are needed to further expand access.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias de la Mama / Supervivientes de Cáncer Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Ann Behav Med Asunto de la revista: CIENCIAS DO COMPORTAMENTO Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias de la Mama / Supervivientes de Cáncer Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Ann Behav Med Asunto de la revista: CIENCIAS DO COMPORTAMENTO Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido