[Changes in the kinetic characteristics of reactions catalyzed by erythrocyte delta-aminolevulinate dehydratase in experimental lead poisoning in rats]. / Izmenenie kineticheskikh kharakteristik reaktsii, kataliziruemoi delta-aminolevulinatdegidratazoi éritrotsitov, pri éksperimental'no svintsovoi intoksikatsii u krys.
Vopr Med Khim
; 32(4): 94-7, 1986.
Article
en Ru
| MEDLINE
| ID: mdl-3765504
An increase in values of both kinetic parameters (Km and Vmax) of the delta-aminolevulinate dehydratase reaction was observed in blood of rats poisoned with lead. The Km value of the reaction was increased, while Vmax--decreased, after addition of Pb2+ into rat blood in vitro. The results obtained as well as the data published in literature suggest that a compensatory mechanism appears to function in vivo, where a substrate, delta-aminolevulenic acid, plays a triggering role.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Eritrocitos
/
Porfobilinógeno Sintasa
/
Intoxicación por Plomo
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Med Khim
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Rusia