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Total neoadjuvant therapy for locally advanced rectal cancer: a narrative review.
Sellés, Elías Gomis; Pieretti, Daniela Gonsalves; Higuero, Paula Peleteiro; Del Portillo, Elisabet González; Macías, Virginia Morillo; Domínguez, María Mateos; Mateos, Raquel Fuentes; Campos, Fernando Lopez; Díaz-Gavela, Ana Aurora; Ferraris, Gustavo; Couñago, Felipe.
Afiliación
  • Sellés EG; Department of Radiation Oncology, University Hospital Virgen del Rocío, Biomedical Institute of Seville (IBIS)/CSIC/University of Seville, Seville, 41013, Spain.
  • Pieretti DG; Department of Radiation Oncology, Genesiscare, Madrid, 28002, Spain.
  • Higuero PP; Department of Radiation Oncology, University Hospital Santiago de Compostela, 15706, Santiago de Compostela, Spain.
  • Del Portillo EG; Department of Radiation Oncology, University Hospital La Paz, Madrid, 28046, Spain.
  • Macías VM; Department of Radiation Oncology, Castellón Provincial Hospital, Castellón, 12002, Spain.
  • Domínguez MM; Department of Radiation Oncology, Genesiscare, Madrid, 28002, Spain.
  • Mateos RF; Department of Medical Oncology, University Hospital Ramón y Cajal, Madrid, 28034, Spain.
  • Campos FL; Radiation Oncology Department, University Hospital Ramon y Cajal, Madrid, 28034, Spain.
  • Díaz-Gavela AA; Quironsalud Madrid University Hospital, Radiation Therapy Department, Medicine Department, School of Biomedical Sciences, Universidad Europea, Madrid, 28223, Spain.
  • Ferraris G; Radiotherapy Unit, Centro de Radioterapia Dean Funes, Córdoba, X5003 CVY, Argentina.
  • Couñago F; San Francisco de Asís and La Milagrosa Hospitals, GenesisCare, Madrid, 28002, Spain.
Future Oncol ; 19(25): 1753-1768, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37650764
Locally advanced rectal cancer has traditionally been treated with chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. However, a new strategy, total neoadjuvant therapy, involves the administration of CRT and neoadjuvant chemotherapy with the aim of eradicating micrometastases earlier and achieving greater control of the disease. The use of total neoadjuvant therapy has shown higher rates of pathological complete response and resectability compared with CRT, including improved survival. Nevertheless, distant relapse is the main cause of morbidity and mortality in locally advanced rectal cancer. To address this, new biomarkers are being developed to predict disease response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Neoplasias Primarias Secundarias Límite: Humans Idioma: En Revista: Future Oncol Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Neoplasias Primarias Secundarias Límite: Humans Idioma: En Revista: Future Oncol Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido