Clinical and laboratory effects of nifedipine in Raynaud's phenomenon.
Rheumatol Int
; 6(2): 85-8, 1986.
Article
en En
| MEDLINE
| ID: mdl-3764307
The calcium channel blocking drug nifedipine was shown to be more effective than placebo as a treatment for Raynaud's phenomenon. Given in a dose of 10 mg four times a day it was well tolerated and reduced both the frequency and the severity of vasospastic attacks. There was, however, a large individual variation in response and while approximately half the patients showed marked improvement others showed no improvement at all. Patients with idiopathic Raynaud's phenomenon responded more favourably than those with systemic sclerosis. Nifedipine was shown to inhibit mitogen-induced lymphocyte proliferation but only in patients who responded to the drug clinically. Calcium channel blocking drugs may therefore have potential as immunoregulatory agents.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Raynaud
/
Nifedipino
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Rheumatol Int
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Alemania