Your browser doesn't support javascript.
loading
HLA-G alleles and their impacts on placental HSV-1 infection in women from southern Brazil.
Tornatore, Michele; Amaral, Suélen Cavalheiro; Alves, Brunna M; de Oliveira, Gisele Rodrigues; Finger-Jardim, Fabiana; Avila, Emiliana Claro; Pivato, Andressa Fernandes; Lobato, Rubens Caurio; Chies, José Artur Bogo; Ellwanger, Joel Henrique; Soares, Esmeralda A; Sánchez-Luquez, Karen; Gonçalves, Carla Vitola; Martínez, Ana Maria Barral de; Soares, Marcelo A; da Hora, Vanusa Pousada.
Afiliación
  • Tornatore M; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Amaral SC; Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil.
  • Alves BM; Post-Graduate Program in Oncovirology, Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ, Brazil.
  • de Oliveira GR; Post-Graduate Program in Oncovirology, Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ, Brazil.
  • Finger-Jardim F; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Avila EC; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Pivato AF; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Lobato RC; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Chies JAB; Laboratory of Immunobiology and Immunogenetics, Post-Graduate Program in Genetics and Molecular Biology (PPGBM), Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Ellwanger JH; Laboratory of Immunobiology and Immunogenetics, Post-Graduate Program in Genetics and Molecular Biology (PPGBM), Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Soares EA; Post-Graduate Program in Oncovirology, Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ, Brazil.
  • Sánchez-Luquez K; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Gonçalves CV; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Martínez AMB; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Soares MA; Post-Graduate Program in Oncovirology, Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ, Brazil; Department of Genetics, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
  • da Hora VP; Post-Graduate Program in Health Sciences, Faculty of Medicine, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil. Electronic address: dahoravp@gmail.com.
J Reprod Immunol ; 159: 104134, 2023 09.
Article en En | MEDLINE | ID: mdl-37634319
The Human Leukocyte Antigen G (HLA-G) is an immunoregulatory molecule with a critical role in pregnancy success. HLA-G alleles are associated with differential susceptibility to multiple conditions, including gestational problems, infectious diseases, and viral persistence. Of note, both herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) can impair HLA-G expression, interfering with HLA-G-associated immunoregulation. On the other hand, the impacts of HLA-G alleles on susceptibility to Herpesviridae infection is a neglected issue. Therefore, this study evaluated HLA-G allele frequencies and their associations with placental Herpesviridae infection in women from southern Brazil. Placenta samples were collected soon after delivery, and detection of viral DNA of HSV-1, HSV-2 and human cytomegalovirus (HCMV) was performed by polymerase chain reaction (PCR). A fragment of HLA-G (exons 2-4) was amplified by PCR, sequenced, and analyzed to allele determination. One hundred and seventy women had their alleles determined. Overall, 25 HLA-G alleles were found, distributed into 56 different genotypes. The most frequent alleles were G* 01:01:01 and G* 01:01:02, found in 37.9 % and 16.5 % of samples, respectively. Among the 170 women, 89 (52.4 %) tested positive for Herpesviridae DNA in the placenta, 55 (32.3 %) tested negative, 3 (1.8 %) were negative for HSV-1 and HSV-2 (with absent HCMV data), and 23 (13.5 %) were undetermined. The G* 01:01:01 allele was significantly associated with an increased risk of placental HSV-1 infection (p = 0.0151; OR=1.837; IC=1.108-3.045). This study describes new information concerning placental HLA-G alleles in women from southern Brazil and helps explain how genetic background can modify susceptibility to placental infections.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Herpesvirus Humano 1 / Herpes Simple Límite: Female / Humans / Pregnancy País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Reprod Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Herpesvirus Humano 1 / Herpes Simple Límite: Female / Humans / Pregnancy País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Reprod Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Irlanda