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Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Graboski, Amanda L; Kowalewski, Mark E; Simpson, Joshua B; Cao, Xufeng; Ha, Mary; Zhang, Jianan; Walton, William G; Flaherty, Daniel P; Redinbo, Matthew R.
Afiliación
  • Graboski AL; Department of Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kowalewski ME; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
  • Simpson JB; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
  • Cao X; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
  • Ha M; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
  • Zhang J; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
  • Walton WG; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
  • Flaherty DP; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
  • Redinbo MR; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: redinbo@unc.edu.
Cell Chem Biol ; 30(11): 1402-1413.e7, 2023 11 16.
Article en En | MEDLINE | ID: mdl-37633277
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Microbioma Gastrointestinal Límite: Animals / Humans Idioma: En Revista: Cell Chem Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Microbioma Gastrointestinal Límite: Animals / Humans Idioma: En Revista: Cell Chem Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos