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Paving the Way for Memory Enhancement: Development and Examination of a Neurofeedback System Targeting the Medial Temporal Lobe.
Koizumi, Koji; Kunii, Naoto; Ueda, Kazutaka; Nagata, Keisuke; Fujitani, Shigeta; Shimada, Seijiro; Nakao, Masayuki.
Afiliación
  • Koizumi K; Department of Mechanical Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
  • Kunii N; Department of Neurosurgery, The University of Tokyo, Tokyo 113-8655, Japan.
  • Ueda K; Department of Mechanical Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
  • Nagata K; Department of Neurosurgery, The University of Tokyo, Tokyo 113-8655, Japan.
  • Fujitani S; Department of Neurosurgery, The University of Tokyo, Tokyo 113-8655, Japan.
  • Shimada S; Department of Neurosurgery, The University of Tokyo, Tokyo 113-8655, Japan.
  • Nakao M; Department of Mechanical Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
Biomedicines ; 11(8)2023 Aug 13.
Article en En | MEDLINE | ID: mdl-37626758
Neurofeedback (NF) shows promise in enhancing memory, but its application to the medial temporal lobe (MTL) still needs to be studied. Therefore, we aimed to develop an NF system for the memory function of the MTL and examine neural activity changes and memory task score changes through NF training. We created a memory NF system using intracranial electrodes to acquire and visualise the neural activity of the MTL during memory encoding. Twenty trials of a tug-of-war game per session were employed for NF and designed to control neural activity bidirectionally (Up/Down condition). NF training was conducted with three patients with drug-resistant epilepsy, and we observed an increasing difference in NF signal between conditions (Up-Down) as NF training progressed. Similarities and negative correlation tendencies between the transition of neural activity and the transition of memory function were also observed. Our findings demonstrate NF's potential to modulate MTL activity and memory encoding. Future research needs further improvements to the NF system to validate its effects on memory functions. Nonetheless, this study represents a crucial step in understanding NF's application to memory and provides valuable insights into developing more efficient memory enhancement strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza