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Cardiovascular mortality by cancer risk stratification in patients with localized prostate cancer: a SEER-based study.
Luo, Zehao; Chi, Kaiyi; Zhao, Hongjun; Liu, Linglong; Yang, Wenting; Luo, Zhijuan; Liang, Yinglan; Zeng, Liangjia; Zhou, Ruoyun; Feng, Manting; Li, Yemin; Hua, Guangyao; Rao, Huying; Lin, Xiaozhen; Yi, Min.
Afiliación
  • Luo Z; Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Chi K; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
  • Zhao H; Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Liu L; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
  • Yang W; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
  • Luo Z; Department of Clinical Medicine, The Sixth Affiliated Hospital of Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan, China.
  • Liang Y; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
  • Zeng L; Department of Anesthesiology, The Second Clinical College of Guangzhou Medical University, Guangzhou, China.
  • Zhou R; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
  • Feng M; Department of Medical Imageology, The Second Clinical College of Guangzhou Medical University, Guangzhou, China.
  • Li Y; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
  • Hua G; Department of Clinical Medicine, The Third Clinical College of Guangzhou Medical University, Guangzhou, China.
  • Rao H; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
  • Lin X; Department of Anesthesiology, The Second Clinical College of Guangzhou Medical University, Guangzhou, China.
  • Yi M; Cardiovascular Medicine and Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou, China.
Front Cardiovasc Med ; 10: 1130691, 2023.
Article en En | MEDLINE | ID: mdl-37614944
Purpose: The risk of cardiovascular disease (CVD) mortality in patients with localized prostate cancer (PCa) by risk stratification remains unclear. The aim of this study was to determine the risk of CVD death in patients with localized PCa by risk stratification. Patients and methods: Population-based study of 340,806 cases in the Surveillance, Epidemiology, and End Results (SEER) database diagnosed with localized PCa between 2004 and 2016. The proportion of deaths identifies the primary cause of death, the competing risk model identifies the interaction between CVD and PCa, and the standardized mortality rate (SMR) quantifies the risk of CVD death in patients with PCa. Results: CVD-related death was the leading cause of death in patients with localized PCa, and cumulative CVD-related death also surpassed PCa almost as soon as PCa was diagnosed in the low- and intermediate-risk groups. However, in the high-risk group, CVD surpassed PCa approximately 90 months later. Patients with localized PCa have a higher risk of CVD-related death compared to the general population and the risk increases steadily with survival (SMR = 4.8, 95% CI 4.6-5.1 to SMR = 13.6, 95% CI 12.8-14.5). Conclusions: CVD-related death is a major competing risk in patients with localized PCa, and cumulative CVD mortality increases steadily with survival time and exceeds PCa in all three stratifications (low, intermediate, and high risk). Patients with localized PCa have a higher CVD-related death than the general population. Management of patients with localized PCa requires attention to both the primary cancer and CVD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza