Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.
J Med Chem
; 29(10): 2117-9, 1986 Oct.
Article
en En
| MEDLINE
| ID: mdl-3761327
10-Acetyl-5,8-dideazafolic acid has been synthesized in good yield from the parent compound, 5,8-dideazafolic acid. This quinazoline folate analogue showed no activity as a substrate for the folate-requiring de novo purine biosynthetic enzyme glycinamide ribonucleotide transformylase isolated from the murine lymphoma cell line L5178Y, but proved to be a potent competitive inhibitor, Ki = 1.3 microM, of the purified enzyme.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aciltransferasas
/
Transferasas de Hidroximetilo y Formilo
/
Ácido Fólico
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos