Your browser doesn't support javascript.
loading
Association of hyperhomocysteinemia and chronic kidney disease in the general population: a systematic review and meta-analysis.
Chen, Wei; Feng, Jihua; Ji, Pan; Liu, Yani; Wan, Huan; Zhang, Jianfeng.
Afiliación
  • Chen W; Guangxi Health Commission key Laboratory of Emergency and Critical Medicine, The Second Affiliated Hospital of Guangxi, Medical University, Nanning, China.
  • Feng J; Guangxi Health Commission key Laboratory of Emergency and Critical Medicine, The Second Affiliated Hospital of Guangxi, Medical University, Nanning, China.
  • Ji P; Guangxi Health Commission key Laboratory of Emergency and Critical Medicine, The Second Affiliated Hospital of Guangxi, Medical University, Nanning, China.
  • Liu Y; Guangxi Health Commission key Laboratory of Emergency and Critical Medicine, The Second Affiliated Hospital of Guangxi, Medical University, Nanning, China.
  • Wan H; Guangxi Health Commission key Laboratory of Emergency and Critical Medicine, The Second Affiliated Hospital of Guangxi, Medical University, Nanning, China.
  • Zhang J; Guangxi Health Commission key Laboratory of Emergency and Critical Medicine, The Second Affiliated Hospital of Guangxi, Medical University, Nanning, China. Zhangjianfeng@gxmu.edu.cn.
BMC Nephrol ; 24(1): 247, 2023 08 23.
Article en En | MEDLINE | ID: mdl-37612681
BACKGROUND: Increasing evidence shows that an elevated homocysteine(Hcy) level is associated with an increased risk of chronic kidney disease (CKD). This study systematically evaluated the correlation between homocysteine level and the incidence of CKD reported in cohort and cross-sectional studies. METHODS: We searched electronic databases and reference lists for relevant articles. 4 cohort studies and 7 cross-sectional studies including 79,416 patients were analyzed in a meta-analysis. Hyperhomocysteinemia was defined as a Hcy level > 15 µmol/L, which was the criterium used in previous studies. Meta-analyses were conducted of literature searches from online databases such as PubMed, Embase, Cochrane and Scopus. Computed pooled adjusted odds ratios with corresponding 95% confidence intervals (95% CI) were used to estimate the risk of new-onset CKD according to Hcy levels in the general population. RESULTS: People with high Hcy levels were more likely to suffer from CKD than people with normal Hcy levels (pooled OR, 2.09; 95% CI, 1.72-2.55). This positive relationship persisted across different study types such as cohort studies (summary OR, 2.2; 95% CI, 1.55-3.13) and cross-sectional studies (summary OR, 2.07; 95% CI, 1.63-2.63). CONCLUSIONS: People with hyperhomocysteinemia have a higher incidence of CKD, Hyperhomocysteinemia may also be an independent risk factor for CKD in the general population.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperhomocisteinemia / Insuficiencia Renal Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperhomocisteinemia / Insuficiencia Renal Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido