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Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.
Hollingsworth, Scott A; Noland, Cameron L; Vroom, Karin; Saha, Anasuya; Sam, Miranda; Gao, Qinshan; Zhou, Haihong; Grandy, David U; Singh, Sujata; Wen, Zhiyun; Warren, Christopher; Ma, Xiaohong Shirley; Malashock, Daniel; Galli, Jennifer; Go, Gwenny; Eddins, Michael; Mayhood, Todd; Sathiyamoorthy, Karthik; Fridman, Arthur; Raoufi, Fahimeh; Gomez-Llorente, Yacob; Patridge, Andrea; Tang, Yinyan; Chen, Shi-Juan; Bailly, Marc; Ji, Chengjie; Kingsley, Laura J; Cheng, Alan C; Geierstanger, Bernhard H; Gorman, Daniel M; Zhang, Lan; Pande, Kalyan.
Afiliación
  • Hollingsworth SA; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Noland CL; Molecular Structure and Design, Bristol-Myers Squibb Research and Development, 700 Bay Road, Redwood City, CA, 94063, USA.
  • Vroom K; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Saha A; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Sam M; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Gao Q; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Zhou H; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Grandy DU; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Singh S; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Wen Z; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Warren C; Infectious Disease and Vaccine Discovery, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Ma XS; Infectious Disease and Vaccine Discovery, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Malashock D; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Galli J; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Go G; Infectious Disease and Vaccine Discovery, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Eddins M; Infectious Disease and Vaccine Discovery, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Mayhood T; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Sathiyamoorthy K; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Fridman A; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Raoufi F; Data Science and Informatics, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ, 07065, USA.
  • Gomez-Llorente Y; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Patridge A; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Tang Y; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Chen SJ; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Bailly M; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Ji C; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Kingsley LJ; NovaBioAssays, LLC, 52 Dragon Ct, Woburn, MA, 01801, USA.
  • Cheng AC; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Geierstanger BH; Boehringer Ingelheim, 900 Ridgebury Rd, Ridgefield, CT, 06877, USA.
  • Gorman DM; Computational and Structural Chemistry, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Zhang L; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
  • Pande K; Discovery Biologics, Merck & Co., Inc., 213 East Grand Ave., South San Francisco, CA, 94080, USA.
Sci Rep ; 13(1): 13668, 2023 08 22.
Article en En | MEDLINE | ID: mdl-37608223
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Camélidos del Nuevo Mundo / Anticuerpos de Dominio Único / COVID-19 Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Camélidos del Nuevo Mundo / Anticuerpos de Dominio Único / COVID-19 Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido