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Charged chiral derivatization for enantioselective imaging of D-,L-2-hydroxyglutaric acid using ion mobility spectrometry/mass spectrometry.
Sugiyama, Eiji; Nishiya, Yuki; Yamashita, Kenji; Hirokawa, Ryo; Iinuma, Yoshiteru; Nirasawa, Takashi; Mizuno, Hajime; Hamashima, Yoshitaka; Todoroki, Kenichiro.
Afiliación
  • Sugiyama E; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp.
  • Nishiya Y; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp.
  • Yamashita K; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp.
  • Hirokawa R; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp.
  • Iinuma Y; Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, 904-0495, Japan.
  • Nirasawa T; Daltonics Division, Bruker Japan K.K., Moriyacho Kanagawa-ku, Yokohama-shi, Kanagawa 221-0022, Japan.
  • Mizuno H; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp.
  • Hamashima Y; Laboratory of Analytical Chemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, 468-8503, Japan.
  • Todoroki K; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp.
Chem Commun (Camb) ; 59(73): 10916-10919, 2023 Sep 12.
Article en En | MEDLINE | ID: mdl-37606059
A newly synthesized charged chiral tag-enabled enantioselective imaging of D-,L-2-hydroxyglutaric acid, which are independently associated with the regulation of DNA methylation. The tag-conjugated diastereomers were ionized efficiently through MALDI, separated by ion mobility spectrometry, and further separated from other molecules in mass spectrometry. On-tissue chiral derivatization using the tag facilitated the visualization of different distributions of the two isomers in the mouse testis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico por Imagen / Espectrometría de Movilidad Iónica Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico por Imagen / Espectrometría de Movilidad Iónica Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido