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Prevalence of cancer in patients with hypothyroidism: Analysis using big data tools.
Díez, Juan J; Cabrera, Luis; Iglesias, Pedro; Benavent, María; Argüello, Guillermo; López, Guillermo; Parralejo, Alejandro; Leal, Javier.
Afiliación
  • Díez JJ; Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda, Madrid, Spain; Departamento de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: juanjose.diez@
  • Cabrera L; Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda, Madrid, Spain; Departamento de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
  • Iglesias P; Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda, Madrid, Spain; Departamento de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
  • Benavent M; MedSavana S.L., Madrid, Spain.
  • Argüello G; MedSavana S.L., Madrid, Spain.
  • López G; MedSavana S.L., Madrid, Spain.
  • Parralejo A; MedSavana S.L., Madrid, Spain.
  • Leal J; Servicio de Informática, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda, Madrid, Spain.
Endocrinol Diabetes Nutr (Engl Ed) ; 70 Suppl 3: 50-58, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37598005
OBJECTIVE: To evaluate the frequency of different types of cancer in patients diagnosed with hypothyroidism using big data methodology on the Savana Manager platform. METHODS: An observational, retrospective study was carried out using electronic medical record (EMR) data from the Hospital Universitario Puerta de Hierro Majadahonda (Madrid). Information from the EMRs was extracted using artificial intelligence techniques and analysed using the Savana Manager v3.0 software. Searches were performed using the term "hypothyroidism" and the terms corresponding to the tumours analysed. RESULTS: Of a total population of 506,749 patients, 23,570 (4.7%) were diagnosed with hypothyroidism. Patients with this diagnosis had a significantly higher frequency of cancer than that found in non-hypothyroid subjects (OR 2.09, 95% confidence interval [CI] 2.01-2.17). This higher frequency was found both in women (OR 1.99, 95% CI 1.90-2.08) and in men (OR 2.83, 95% CI 2.63-3.05). However, this higher frequency of cancer was not observed in hypothyroid patients older than 60 years (OR 0.97, 95% CI 0.92-1.02). Although the frequency of most of the neoplasms studied individually was higher in the population with hypothyroidism, we observed that hypothyroid patients over 60 years of age had a significant decrease in the frequency of prostate, lung, colorectal, and liver cancer. CONCLUSION: Data from this hospital cohort suggest that there is a significant association between the diagnosis of hypothyroidism and cancer. However, this association is less evident in hypothyroid patients older than 60 years.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipotiroidismo / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocrinol Diabetes Nutr (Engl Ed) Año: 2023 Tipo del documento: Article Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipotiroidismo / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocrinol Diabetes Nutr (Engl Ed) Año: 2023 Tipo del documento: Article Pais de publicación: España