Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model.

van Leeuwen, L Leonie; Ruigrok, Mitchel J R; Kessler, Benedikt M; Leuvenink, Henri G D; Olinga, Peter

van Leeuwen, L Leonie; Ruigrok, Mitchel J R; Kessler, Benedikt M; Leuvenink, Henri G D; Olinga, Peter.

Afiliación

van Leeuwen LL; Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ruigrok MJR; Nuffield Department of Medicine, Centre for Medicines Discovery, Target Discovery Institute, University of Oxford, Oxford, UK.
Kessler BM; Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Leuvenink HGD; Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Olinga P; Nuffield Department of Medicine, Centre for Medicines Discovery, Target Discovery Institute, University of Oxford, Oxford, UK.

Br J Pharmacol ; 181(3): 464-479, 2024 02.

Article en En | MEDLINE | ID: mdl-37596999

Asunto(s)

Trasplante de Riñón; Pirazoles; Quinolinas; Porcinos; Animales; Trasplante de Riñón/efectos adversos; Riñón/patología; Perfusión; Fibrosis

Palabras clave

fibrogenesis; interstitial fibrosis and tubular atrophy; ischaemia-reperfusion injury; normothermic machine perfusion; renal transplantation; repurposing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Quinolinas / Trasplante de Riñón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Br J Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido

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