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Genetic diversity, recombination and cross-species transmission of a waterbird gammacoronavirus in the wild.
François, Sarah; Nazki, Salik; Vickers, Stephen H; Fournié, Guillaume; Perrins, Christopher M; Broadbent, Andrew J; Pybus, Oliver G; Hill, Sarah C.
Afiliación
  • François S; Department of Biology, University of Oxford, South Park Road, Oxford, OX1 3SY, UK.
  • Nazki S; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7FZ, UK.
  • Vickers SH; The Pirbright Institute, Ash Rd, Pirbright, Woking GU24 0NF, UK.
  • Fournié G; Department of Pathobiology and Population Science, Royal Veterinary College, Hawkshead Lane, Hatfield, AL9 7TA, UK.
  • Perrins CM; Department of Pathobiology and Population Science, Royal Veterinary College, Hawkshead Lane, Hatfield, AL9 7TA, UK.
  • Broadbent AJ; Université de Lyon, INRAE, VetAgro Sup, UMR EPIA, Marcy l'Etoile, France.
  • Pybus OG; Université Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Saint-Gènes-Champanelle, France.
  • Hill SC; Department of Biology, University of Oxford, South Park Road, Oxford, OX1 3SY, UK.
J Gen Virol ; 104(8)2023 08.
Article en En | MEDLINE | ID: mdl-37589541
Viruses emerging from wildlife can cause outbreaks in humans and domesticated animals. Predicting the emergence of future pathogens and mitigating their impacts requires an understanding of what shapes virus diversity and dynamics in wildlife reservoirs. In order to better understand coronavirus ecology in wild species, we sampled birds within a coastal freshwater lagoon habitat across 5 years, focussing on a large population of mute swans (Cygnus olor) and the diverse species that they interact with. We discovered and characterised the full genome of a divergent gammacoronavirus belonging to the Goose coronavirus CB17 species. We investigated the genetic diversity and dynamics of this gammacoronavirus using untargeted metagenomic sequencing of 223 faecal samples from swans of known age and sex, and RT-PCR screening of 1632 additional bird samples. The virus circulated persistently within the bird community; virus prevalence in mute swans exhibited seasonal variations, but did not change with swan age-class or epidemiological year. One whole genome was fully characterised, and revealed that the virus originated from a recombination event involving an undescribed gammacoronavirus species. Multiple lineages of this gammacoronavirus co-circulated within our study population. Viruses from this species have recently been detected in aquatic birds from both the Anatidae and Rallidae families, implying that host species habitat sharing may be important in shaping virus host range. As the host range of the Goose coronavirus CB17 species is not limited to geese, we propose that this species name should be updated to 'Waterbird gammacoronavirus 1'. Non-invasive sampling of bird coronaviruses may provide a tractable model system for understanding the evolutionary and cross-species dynamics of coronaviruses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Coronavirus / Coronavirus / Anseriformes / Gammacoronavirus Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Gen Virol Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Coronavirus / Coronavirus / Anseriformes / Gammacoronavirus Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Gen Virol Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido