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Multiomic analysis of HER2-enriched and AR-positive breast carcinoma with apocrine differentiation and an oligometastatic course: a case report.
Poggiali, Brando; Ponzetti, Agostino; Malerba, Marica; Landuzzi, Fabio; Furia, Federica; Charrance, Debora; Trova, Sara; Perseghin, Vittoria; Falcone, Patrizia A; Alliod, Valentina; Malossi, Alessandra; Carassai, Pierpaolo; Familiari, Ubaldo; Vecchi, Manuela; Gustincich, Stefano; Schena, Marina; Cavalli, Andrea; Coppe, Alessandro.
Afiliación
  • Poggiali B; CComputational and Chemical Biology, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Ponzetti A; Oncologia e Ematologia oncologica, Ospedale Umberto Parini, Aosta, Italy.
  • Malerba M; CComputational and Chemical Biology, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Landuzzi F; CComputational and Chemical Biology, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Furia F; CComputational and Chemical Biology, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Charrance D; CComputational and Chemical Biology, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Trova S; Non-Coding RNAs and RNA-Based Therapeutics, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Perseghin V; CComputational and Chemical Biology, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Falcone PA; Biologia Molecolare Oncologica e Virologica, Analisi Cliniche, Ospedale Umberto Parini, Aosta, Italy.
  • Alliod V; Oncologia e Ematologia oncologica, Ospedale Umberto Parini, Aosta, Italy.
  • Malossi A; Oncologia e Ematologia oncologica, Ospedale Umberto Parini, Aosta, Italy.
  • Carassai P; Anatomia Patologica, Ospedale Umberto Parini, Aosta, Italy.
  • Familiari U; Anatomia Patologica, Ospedale Umberto Parini, Aosta, Italy.
  • Vecchi M; Non-Coding RNAs and RNA-Based Therapeutics, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Gustincich S; Non-Coding RNAs and RNA-Based Therapeutics, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Schena M; Oncologia e Ematologia oncologica, Ospedale Umberto Parini, Aosta, Italy.
  • Cavalli A; CComputational and Chemical Biology, Italian Institute of Technology (IIT), CMP3VdA, Aosta, Italy.
  • Coppe A; Centre Européen de Calcul Atomique et Moléculaire (CECAM), Ecole Polytechnique Fé dérale de Lausanne, Lausanne, Switzerland.
Front Oncol ; 13: 1240865, 2023.
Article en En | MEDLINE | ID: mdl-37583932
Breast carcinoma is the most prevalent cancer among women globally. It has variable clinical courses depending on the stage and clinical-biological features. This case report describes a 56-year-old female with invasive breast cancer without estrogen or progesterone receptor expression, with apocrine differentiation, and with no germline variants in the BRCA1 and BRCA2 genes. Throughout the clinical course, the patient exhibited discordant results for HER2 in immunohistochemistry and in situ hybridization. During the second relapse, the disease displayed apocrine microscopic features. The tumor underwent analysis for the androgen receptor, GCDFP-15, RNA-seq, and whole-genome sequencing (WGS) to identify the breast cancer subtype and to characterize the cancer genome. Our bioinformatic analysis revealed 20,323 somatic SNV/Indels, including five mutations in cancer-related genes that are believed to be responsible for the tumor's development. Two of these mutations were found in the PIK3CA and TP53 genes. Furthermore, the tumor tissue exhibited large copy number alterations to the chromosomes, which could impact gene expression through complex mechanisms and contribute to the tumor phenotype. Clustering algorithms applied on RNA-sequencing data categorized this cancer as a HER2+ subtype. The second-line capecitabine chemotherapy treatment is ongoing, and the patient is responding well. Bioinformatic results support the current treatment decision and open the way to further treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza