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Prehabilitation in older patients prior to elective cardiac procedures (PRECOVERY): study protocol of a multicenter randomized controlled trial.
Steinmetz, Carolin; Heinemann, Stephanie; Kutschka, Ingo; Hasenfuß, Gerd; Asendorf, Thomas; Remppis, Bjoern Andrew; Knoglinger, Ernst; Grefe, Clemens; Albes, Johannes Maximilian; Baraki, Hassina; Baumbach, Christian; Brunner, Susanne; Ernst, Susann; Harringer, Wolfgang; Heider, Dirk; Heidkamp, Daniela; Herrmann-Lingen, Christoph; Hummers, Eva; Kocar, Thomas; König, Hans-Helmut; Krieger, Simone; Liebold, Andreas; Martens, Andreas; Matzeder, Marcus; Mellert, Friedrich; Müller, Christiane; Puls, Miriam; Reiss, Nils; Schikora, Martin; Schmidt, Thomas; Vestweber, Martin; Sadlonova, Monika; von Arnim, Christine A F.
Afiliación
  • Steinmetz C; Department of Geriatrics, University of Goettingen Medical Center, Robert-Koch-Straße 40, 37075, Goettingen, Germany.
  • Heinemann S; Department of Geriatrics, University of Goettingen Medical Center, Robert-Koch-Straße 40, 37075, Goettingen, Germany.
  • Kutschka I; Department of Cardiovascular and Thoracic Surgery, University of Goettingen Medical Center, Goettingen, Germany.
  • Hasenfuß G; German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Goettingen, Germany.
  • Asendorf T; German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Goettingen, Germany.
  • Remppis BA; Department of Cardiology and Pneumology, University of Goettingen Medical Center, Goettingen, Germany.
  • Knoglinger E; Department of Medical Statistics, University of Goettingen Medical Center, Goettingen, Germany.
  • Grefe C; Heart and Vascular Center Bad Bevensen, Bad Bevensen, Germany.
  • Albes JM; Kirchberg Clinic, Bad Lauterberg, Germany.
  • Baraki H; Clinic and Rehabilitation Center Lippoldsberg, Wesertal, Germany.
  • Baumbach C; Immanuel Clinic Bernau, Brandenburg Heart Center, Bernau, Germany.
  • Brunner S; Department of Cardiovascular and Thoracic Surgery, University of Goettingen Medical Center, Goettingen, Germany.
  • Ernst S; German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Goettingen, Germany.
  • Harringer W; Heart and Vascular Center Bad Bevensen, Bad Bevensen, Germany.
  • Heider D; Clinic Fallingbostel, Bad Fallingbostel, Germany.
  • Heidkamp D; ZAR Center for Outpatient Rehabilitation GmbH, Ulm, Germany.
  • Herrmann-Lingen C; Department of Cardiac, Thoracic and Vascular Surgery, Braunschweig Municipal Hospital, Brunswick, Germany.
  • Hummers E; Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg-Eppendorf, Germany.
  • Kocar T; Rehabilitation Center Oldenburg, Oldenburg, Germany.
  • König HH; German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Goettingen, Germany.
  • Krieger S; Department of Psychosomatic Medicine and Psychotherapy, University of Goettingen Medical Center, Goettingen, Germany.
  • Liebold A; Department of General Practice, University of Goettingen Medical Center, Goettingen, Germany.
  • Martens A; Geriatric Center Ulm, Ulm, Germany.
  • Matzeder M; Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg-Eppendorf, Germany.
  • Mellert F; Department of Psychosomatic Medicine and Psychotherapy, University of Goettingen Medical Center, Goettingen, Germany.
  • Müller C; Department for Thoracic, Cardiac and Vascular Surgery, Ulm University Medical Center, Ulm, Germany.
  • Puls M; Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
  • Reiss N; AOK Health Insurance (AOK Lower Saxony), Helmstedt, Germany.
  • Schikora M; Department of Cardiac Surgery, Oldenburg Hospital, Oldenburg, Germany.
  • Schmidt T; Department of General Practice, University of Goettingen Medical Center, Goettingen, Germany.
  • Vestweber M; German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Goettingen, Germany.
  • Sadlonova M; Department of Cardiology and Pneumology, University of Goettingen Medical Center, Goettingen, Germany.
  • von Arnim CAF; Schüchtermann-Schiller'sche Clinic, Bad Rothenfelde, Germany.
Trials ; 24(1): 533, 2023 Aug 15.
Article en En | MEDLINE | ID: mdl-37582774
BACKGROUND: Previous studies have demonstrated the efficacy of rehabilitation after a cardiovascular procedure. Especially older and multimorbid patients benefit from rehabilitation after a cardiac procedure. Prehabilitation prior to cardiac procedures may also have positive effects on patients' pre- and postoperative outcomes. Results of a current meta-analysis show that prehabilitation prior to cardiac procedures can improve perioperative outcomes and alleviate adverse effects. Germany currently lacks a structured cardiac prehabilitation program for older patients, which is coordinated across healthcare sectors. METHODS: In a randomized, controlled, two-arm parallel group, assessor-blinded multicenter intervention trial (PRECOVERY), we will randomize 422 patients aged 75 years or older scheduled for an elective cardiac procedure (e.g., coronary artery bypass graft surgery or transcatheter aortic valve replacement). In PRECOVERY, patients randomized to the intervention group participate in a 2-week multimodal prehabilitation intervention conducted in selected cardiac-specific rehabilitation facilities. The multimodal prehabilitation includes seven modules: exercise therapy, occupational therapy, cognitive training, psychosocial intervention, disease-specific education, education with relatives, and nutritional intervention. Participants in the control group receive standard medical care. The co-primary outcomes are quality of life (QoL) and mortality after 12 months. QoL will be measured by the EuroQol 5-dimensional questionnaire (EQ-5D-5L). A health economic evaluation using health insurance data will measure cost-effectiveness. A mixed-methods process evaluation will accompany the randomized, controlled trial to evaluate dose, reach, fidelity and adaptions of the intervention. DISCUSSION: In this study, we investigate whether a tailored prehabilitation program can improve long-term survival, QoL and functional capacity. Additionally, we will analyze whether the intervention is cost-effective. This is the largest cardiac prehabilitation trial targeting the wide implementation of a new form of care for geriatric cardiac patients. TRIAL REGISTRATION: German Clinical Trials Register (DRKS; http://www.drks.de ; DRKS00030526). Registered on 30 January 2023.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Rehabilitación Cardiaca Tipo de estudio: Clinical_trials / Qualitative_research / Systematic_reviews Aspecto: Patient_preference Límite: Aged / Humans Idioma: En Revista: Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Rehabilitación Cardiaca Tipo de estudio: Clinical_trials / Qualitative_research / Systematic_reviews Aspecto: Patient_preference Límite: Aged / Humans Idioma: En Revista: Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido