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Future scope of plant-derived bioactive compounds in the management of methicillin-resistant Staphylococcus aureus: In vitro antimicrobial and antivirulence prospects to combat MRSA.
Abdel-Raheem, Sherief M; Abd El-Hamid, Marwa I; Ibrahim, Doaa; El-Malt, Rania M S; El-Ghareeb, Waleed Rizk; Ismail, Hesham A; Al-Sultan, Saad Ibrahim; Meligy, Ahmed M A; ELTarabili, Reham M.
Afiliación
  • Abdel-Raheem SM; Department of Public Health, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Hofuf, 31982, Al-Ahsa, Saudi Arabia; Department of Animal Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt. Electronic address: sdiab@kfu.edu.sa
  • Abd El-Hamid MI; Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt. Electronic address: mero_micro2006@yahoo.com.
  • Ibrahim D; Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. Electronic address: doibrahim@vet.zu.edu.eg.
  • El-Malt RMS; Department of Bacteriology, Animal Health Research Institute, Zagazig Branch, Agriculture Research Center, 44516, Zagazig, Egypt. Electronic address: raniaelmalt@yahoo.com.
  • El-Ghareeb WR; Department of Public Health, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Hofuf, 31982, Al-Ahsa, Saudi Arabia; Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt. Electronic address: welsaid@kfu.edu.sa.
  • Ismail HA; Department of Public Health, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Hofuf, 31982, Al-Ahsa, Saudi Arabia; Food Hygiene Department, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt. Electronic address: hismail@kfu.edu.sa.
  • Al-Sultan SI; Department of Public Health, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Hofuf, 31982, Al-Ahsa, Saudi Arabia.
  • Meligy AMA; Department of Clinical Sciences, Central Lab, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Hofuf, 31982, Al-Ahsa, Saudi Arabia; Department of Physiology, Agricultural Research Center (ARC), Giza, Egypt. Electronic address: amelegi@kfu.edu.sa.
  • ELTarabili RM; Department of Bacteriology, Immunology, and Mycology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt. Electronic address: riham_tarabily@vet.suez.edu.eg.
Microb Pathog ; 183: 106301, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37579824
Methicillin-resistant Staphylococcus aureus (MRSA) is a foremost human and animal pathogen with public health and veterinary significance causing hospital and community infections and contagious bovine mastitis. Due to its ability to develop multidrug resistance (MDR) and its pathogenicity, MRSA infection control is becoming a global concern. Natural antibacterial options are needed to combat MDR development and infectious dissemination. This study investigated the antimicrobial resistance and virulence genes profiling of MRSA isolates and explored the antivirulence efficacy of trans-cinnamaldehyde, thymol, and carvacrol essential oils (EOs) against multivirulent and MDR-MRSA isolates. Thirty six S. aureus isolates (25%) were retrieved, of which 34 (94.4%) were MRSA. A high prevalence of MDR (66.7%) was monitored and all 53 molecularly verified isolates possessed icaA and cna virulence genes. Moreover, 94.1% of these isolates were multivirulent with 23.5% of them carrying icaA, cna, eta, tst, and sea virulence genes. Our data proved superior in vitro antimicrobial and antivirulence activities of trans-cinnamaldehyde, thymol, and carvacrol. They inhibited the growth of multi-virulent and MDR-MRSA isolates and downregulated the transcription of examined virulence genes. Our study suggests using EOs as prospective antimicrobials with excellent antivirulence activities against MRSA isolates. We provided data regarding the eventual role of phytogenics in prevention and control of MRSA infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido