[Modifying effect of methylcobalamin in organ cultures of the mouse kidney when administered transplacentally in combination with N-nitrosoethylurea]. / Modifitsiruiushchee vliianie metilkobalamina v organnykh kul'turakh pochek myshei pri kombinirovannom transplatsentarnom deistvii s N-nitrozoétilmochevinoi.
Eksp Onkol
; 8(4): 23-8, 1986.
Article
en Ru
| MEDLINE
| ID: mdl-3757879
The influence of methylcobalamin (MeCbl) on transplacental effect of N-nitrosoethylurea (NEU) was studied in organ cultures of embryonic tissue of DBA/2 mice by the histoautoradiography (3H TdR). A combined transplacental treatment of pregnant mice with MeCbl and NEU produced a 3.3-fold increase in the frequency of focal hyperplastic growth of epithelium as compared to the effect of NEU alone. Under such conditions the modifying effect of methylcobalamin, coenzyme of methionine synthetase, was probably due to an increase in the proliferative activity of epithelial cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lesiones Precancerosas
/
Vitamina B 12
/
Cocarcinogénesis
/
Etilnitrosourea
/
Neoplasias Renales
/
Intercambio Materno-Fetal
Límite:
Animals
/
Pregnancy
Idioma:
Ru
Revista:
Eksp Onkol
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Ucrania