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Excessive hair cortisol concentration as an indicator of psychological disorders in children.
Brænden, Astrid; Lebena, Andrea; Faresjö, Åshild; Theodorsson, Elvar; Coldevin, Marit; Stubberud, Jan; Zeiner, Pål; Melinder, Annika.
Afiliación
  • Brænden A; Oslo University Hospital, Division of Mental Health and Addiction, Oslo, Norway. Electronic address: asbrae@ous-hf.no.
  • Lebena A; Department of Health, Medicine and Caring Sciences, University of Linköping, Sweden.
  • Faresjö Å; Department of Health, Medicine and Caring Sciences, University of Linköping, Sweden.
  • Theodorsson E; Department of Biomedical and Clinical Science, Division of Clinical Chemistry and Pharmacology, Linköping University, Linköping, Sweden.
  • Coldevin M; Lovisenberg Diaconal Hospital, Nic Waals Institute, Oslo, Norway.
  • Stubberud J; Lovisenberg Diaconal Hospital, Department of Research, Oslo, Norway; University of Oslo, Department of Psychology, Oslo, Norway.
  • Zeiner P; Oslo University Hospital, Division of Mental Health and Addiction, Oslo, Norway; University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
  • Melinder A; Oslo University Hospital, Division of Mental Health and Addiction, Oslo, Norway; University of Oslo, Department of Psychology, Oslo, Norway.
Psychoneuroendocrinology ; 157: 106363, 2023 11.
Article en En | MEDLINE | ID: mdl-37573627
Cortisol in hair is a new biomarker assessing long-term hypothalamic-pituitary-adrenal (HPA) axis activity, which is related to emotion regulation. We compare hair cortisol concentrations (HCC), in clinically referred children with disruptive mood dysregulation disorder (DMDD) (n = 19), children with other types of psychological disorders (n = 48), and healthy subjects (n = 36). We also investigate the association between HCC and irritability, age, and sex. Our results show that children with DMDD or other types of psychological disorders have higher HCC than healthy subjects, p < .001, ηp2 = .39. No difference between children with DMDD and those with other types of psychological disorders was found, p = .91, nor an association between HCC and irritability in the clinical sample, p = .32. We found a significant negative correlation between HCC and age in those with DMDD, r = -0.54, p < .05, but not in the normative sample, r = -0.20, p = .25. No differences in HCC between girls and boys were found in the normative sample, p = .49. Children in need of psychological treatment, including those with DMDD, seem to have dysregulated HPA-axis activity over time. Excessive accumulated cortisol concentrations in hair could be an indicator of a psychological disorder in children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocortisona / Trastornos del Humor Límite: Child / Female / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocortisona / Trastornos del Humor Límite: Child / Female / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido