Your browser doesn't support javascript.
loading
Aberrant p16, p53 and Ki-67 immunohistochemistry staining patterns can distinguish solitary keratoacanthoma from cutaneous squamous cell carcinoma.
Carr, Richard A; Mesiano, Domenico; Heffron, Cynthia; Radonic, Teodora; Wiggins, James; Tso, Simon; Agrawal, Rishi; Cheung, Elaine; Slater, David N; Nichols, Linda; Craig, Paul.
Afiliación
  • Carr RA; Cellular Pathology, South Warwickshire NHS Foundation Trust, Warwick, UK. Electronic address: richard.carr@swft.nhs.uk.
  • Mesiano D; Cellular Pathology, South Warwickshire NHS Foundation Trust, Warwick, UK.
  • Heffron C; Department of Pathology, Cork University Hospital, Cork, Ireland.
  • Radonic T; Department of Pathology, Amsterdam University Medical Center, Netherlands.
  • Wiggins J; Cellular Pathology, South Warwickshire NHS Foundation Trust, Warwick, UK.
  • Tso S; Jephson Dermatology Centre, South Warwickshire NHS Foundation Trust, Warwick, UK.
  • Agrawal R; Histopathology Department, New Cross Hospital, Wolverhampton, UK.
  • Cheung E; Department of Pathology, Queen Elizabeth Hospital, Hong Kong.
  • Slater DN; Chesterfield Royal Hospital, Chesterfield, UK.
  • Nichols L; Department of Statistics, University of Warwick, Coventry, UK.
  • Craig P; Department of Histopathology, Cheltenham General Hospital, Gloucestershire, UK.
Pathology ; 55(6): 772-784, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37573161
Keratoacanthoma (KA) is widely considered a benign, usually self-resolving, neoplasm distinct from cutaneous squamous cell carcinoma (cSCC), while some consider KA to be indistinguishable from cSCC. Published studies indicate utility for p16, p53, Ki-67 immunostaining and elastic van Gieson (EVG) in the assessment of KA and cSCC. We compared clinical features and staining patterns for p16, p53, Ki-67 and EVG in fully excised KA, cSCC with KA-like features (cSCC-KAL) and other cSCC (cSCC-OTHER). Significant differences between KA, cSCC-KAL and cSCC-OTHER were found for head and neck location (20%, 86%, 84%), and duration <5 months (95%, 63%, 36%). KA shows both a mosaic pattern for p16 (>25-90% of neoplasm area) and peripheral graded pattern for p53 (up to 50% moderate and strong nuclear staining) in 92% compared with 0% of cSCC-KAL and 0% of cSCC-OTHER. In contrast, a highly aberrant pattern (usually null) for one or both p16 and p53, was present in 0% of KA, 83.8% of cSCC-KAL and 90.9% of cSCC-OTHER. Abnormal distribution of Ki-67 beyond the peripheral 1-3 cells was uncommon in KA (4.2%) and common in cSCC-KAL (67.6%) and cSCC-OTHER (88.4%). Moderate to striking entrapment of elastic and collagen fibres was present in the majority of KA (84%), cSCC-KAL (81%) and cSCC-OTHER (65%). KA are clinically distinct neoplasms typically of short duration occurring preferentially outside the head and neck and generally lacking aberrations of p16, p53 and Ki-67, compared with cSCC that have high rates of aberrant or highly aberrant p16, p53 and Ki-67, but EVG lacked specificity.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma de Células Escamosas / Queratoacantoma Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Pathology Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma de Células Escamosas / Queratoacantoma Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Pathology Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido