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Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke.
Shaheryar, Zaib Ali; Khan, Mahtab Ahmad; Hameed, Huma; Zaidi, Syed Awais Ali; Anjum, Irfan; Rahman, Muhammad Shafeeq Ur.
Afiliación
  • Shaheryar ZA; Faculty of Pharmacy, The University of Lahore, Lahore, 54000, Pakistan. Electronic address: zaib.shaheryar@pharm.uol.edu.pk.
  • Khan MA; Faculty of Pharmaceutical Sciences, University of Central Punjab (UCP), Lahore, 54000, Pakistan. Electronic address: dean.fop@ucp.edu.pk.
  • Hameed H; Faculty of Pharmaceutical Sciences, University of Central Punjab (UCP), Lahore, 54000, Pakistan. Electronic address: huma.hameed@ucp.edu.pk.
  • Zaidi SAA; Department of Pharmacy, The Sahara University Narowal, Narowal, 51600, Pakistan. Electronic address: awais.ali.phd@gmail.com.
  • Anjum I; Faculty of Pharmacy, The University of Lahore, Lahore, 54000, Pakistan; Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-E-Milat University, Islamabad, Pakistan. Electronic address: anjuum95@yahoo.com.
  • Rahman MSU; Faculty of Pharmaceutical Sciences, University of Central Punjab (UCP), Lahore, 54000, Pakistan. Electronic address: shafeeq.rahman@ucp.edu.pk.
Eur J Pharmacol ; 956: 175990, 2023 Oct 05.
Article en En | MEDLINE | ID: mdl-37572940
During ischemic stroke, higher glucose level linked worse outcomes were reported even in patients without pre-existing diabetes. Evidence suggest that such worse stroke outcomes were mainly due to production of reactive, toxic glucose metabolites that expands oxidative damage inside the brain. As a consequence of high oxidative stress, microvasculature structures and tight junctions compromised their functionally, infarct volume expands and brain edema exacerbates. In a mouse model of ischemic stroke with induced acute hyperglycaemia, Lauric acid (LA) as a natural saturated fatty acid demonstrated neuroprotection by attenuating infarct volume and brain edema. In addition, in the ipsilateral hyperglycaemic brain, the LA significantly increased the expression of tight junction representative protein (occludin) as well as anti-oxidative markers; Manganese superoxide dismutase (Mn) SOD, Extracellular superoxide dismutase (Ec-SOD) and nuclear factor-erythroid factor 2-related factor 2 (Nrf2) in the ipsilateral region against hyperglycemic ischemic stroke. LA treated animals showed a significant reduction in the production of lipid peroxidation products (4-HNE) in the microvascular structures, maintained the blood brain barrier (BBB) integrity. LA linked neuroprotective outcomes were further confirmed by behavioral tests, where functional outcomes and motor coordination were improved significantly. Furthermore, LA treatment enhanced food intake, decreased mortality rate, and net body weight loss. Conclusively, LA modulated ischemic insult exacerbated by hyperglycemia and provided neuroprotection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Isquemia Encefálica / Fármacos Neuroprotectores / Accidente Cerebrovascular / Accidente Cerebrovascular Isquémico / Hiperglucemia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Isquemia Encefálica / Fármacos Neuroprotectores / Accidente Cerebrovascular / Accidente Cerebrovascular Isquémico / Hiperglucemia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos