Role of medullary cholinoceptors in baroreflex bradycardia.
Clin Exp Hypertens A
; 8(6): 1063-79, 1986.
Article
en En
| MEDLINE
| ID: mdl-3757290
Cholinergic receptors present in three medullary nuclei namely, the nucleus tractus solitarii (NTS), nucleus ambiguous (AMB) and the dorsal motor nucleus of the vagus nerve (DMV) have been studied with regard to their role in regulation of heart rate (HR), blood pressure (BP) and baroreceptor reflex activation induced bradycardia in cats. Microinjection of carbachol into NTS was without effect while administration of carbachol or pilocarpine into AMB and DMV elicited dose related decrease in HR without affecting BP. These effects were completely antagonized by ethylbenztropine. Bilateral muscarinic cholinoceptor blockade of either AMB or DMV, with ethylbenztropine, produced a partial inhibition of the baroreflex bradycardia while intracisternal ethylbenztropine completely abolished this reflex response. Involvement of muscarinic cholinoceptors of AMB or DMV in baroreflex mediated adjustments of HR is therefore suggested.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Presorreceptores
/
Bulbo Raquídeo
/
Receptores Muscarínicos
/
Frecuencia Cardíaca
Límite:
Animals
Idioma:
En
Revista:
Clin Exp Hypertens A
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos