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Angiotensin Regulation of Vascular Homeostasis: Exploring the Role of ROS and RAS Blockers.
Koumallos, Nikolaos; Sigala, Evangelia; Milas, Theodoros; Baikoussis, Nikolaos G; Aragiannis, Dimitrios; Sideris, Skevos; Tsioufis, Konstantinos.
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  • Koumallos N; Cardiothoracic Department, Hippokration Hospital of Athens, 11527 Athens, Greece.
  • Sigala E; Cardiothoracic Department, Hippokration Hospital of Athens, 11527 Athens, Greece.
  • Milas T; Cardiothoracic Department, Hippokration Hospital of Athens, 11527 Athens, Greece.
  • Baikoussis NG; Cardiothoracic Department, Hippokration Hospital of Athens, 11527 Athens, Greece.
  • Aragiannis D; Cardiology Department, Hippokration Hospital of Athens, 11527 Athens, Greece.
  • Sideris S; Cardiology Department, Hippokration Hospital of Athens, 11527 Athens, Greece.
  • Tsioufis K; Cardiology Department, Hippokration Hospital of Athens, 11527 Athens, Greece.
Int J Mol Sci ; 24(15)2023 Jul 28.
Article en En | MEDLINE | ID: mdl-37569484
Extensive research has been conducted to elucidate and substantiate the crucial role of the Renin-Angiotensin System (RAS) in the pathogenesis of hypertension, cardiovascular disorders, and renal diseases. Furthermore, the role of oxidative stress in maintaining vascular balance has been well established. It has been observed that many of the cellular effects induced by Angiotensin II (Ang II) are facilitated by reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In this paper, we present a comprehensive overview of the role of ROS in the physiology of human blood vessels, specifically focusing on its interaction with RAS. Moreover, we delve into the mechanisms by which clinical interventions targeting RAS influence redox signaling in the vascular wall.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Hipertensión Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Hipertensión Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza