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Response to Immunization against SARS-CoV-2 and Risk of Omicron Infection in Dialysis Patients: A Prospective Cohort Study.
Werzowa, Johannes; Behanova, Martina; Handisurya, Ammon; Heger, Florian; Indra, Alexander; Holzer, Barbara; Dechat, Thomas; Spitzer, Silvia; Lederer, Sandra; Kraus, Daniel A; Zwerina, Jochen; Fritsch-Stork, Ruth D E.
Afiliación
  • Werzowa J; Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1140 Vienna, Austria.
  • Behanova M; 1st Medical Department, Hanusch Hospital, 1140 Vienna, Austria.
  • Handisurya A; Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1140 Vienna, Austria.
  • Heger F; 1st Medical Department, Hanusch Hospital, 1140 Vienna, Austria.
  • Indra A; Austrian Agency for Health and Food Safety (AGES), 1090 Vienna, Austria.
  • Holzer B; Austrian Agency for Health and Food Safety (AGES), 1090 Vienna, Austria.
  • Dechat T; Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety (AGES), 2340 Moedling, Austria.
  • Spitzer S; Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1140 Vienna, Austria.
  • Lederer S; Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1140 Vienna, Austria.
  • Kraus DA; 1st Medical Department, Hanusch Hospital, 1140 Vienna, Austria.
  • Zwerina J; Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1140 Vienna, Austria.
  • Fritsch-Stork RDE; 1st Medical Department, Hanusch Hospital, 1140 Vienna, Austria.
J Clin Med ; 12(15)2023 Jul 28.
Article en En | MEDLINE | ID: mdl-37568385
It is not well established to what extent previous immunizations offer protection against infections with the SARS-CoV-2 Omicron variant in dialysis patients. We aimed to define the relevant humoral response in dialysis patients using a SARS-CoV-2 IgG chemiluminescence microparticle immunoassay (CMIA) compared to the activity of neutralizing antibodies assessed by a virus neutralization test. Next, we aimed to determine differences in humoral and cellular response levels over time among patients infected or not infected by the Omicron variant of SARS-CoV-2. Immunological parameters of cellular and humoral response to SARS-CoV-2 were analyzed at baseline and after 3 (T3), 6 (T6) and 14 months (T14). In this monocentric cohort study, we followed 110 dialysis patients (mean age 68.4 ± 13.7 years, 60.9% male) for a median of 545 days. We determined an anti-SARS-CoV-2 IgG level of 56.7 BAU/mL as an ideal cut-off value with a J-index of 90.7. Patients infected during the Omicron era had significantly lower (p < 0.001) mean antibody levels at T0 (3.5 vs. 111.2 BAU/mL), T3 (269.8 vs. 699.8 BAU/mL) and T6 (260.2 vs. 513.9 BAU/mL) than patients without Omicron infection. Patients who developed higher antibody levels at the time of the basic immunizations were less likely to become infected with SARS-CoV-2 during the Omicron era. There is a need to adjust the cut-off values for anti-SARS-CoV-2 IgG levels in dialysis patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza