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Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Czarnota-Lydka, Kinga; Sudol-Talaj, Sylwia; Kucwaj-Brysz, Katarzyna; Kurczab, Rafal; Satala, Grzegorz; de Candia, Modesto; Samarelli, Francesco; Altomare, Cosimo Damiano; Carocci, Alessia; Barbarossa, Alexia; Zeslawska, Ewa; Gluch-Lutwin, Monika; Mordyl, Barbara; Kubacka, Monika; Wilczynska-Zawal, Natalia; Jastrzebska-Wiesek, Magdalena; Partyka, Anna; Khan, Nadia; Wiecek, Malgorzata; Nitek, Wojciech; Honkisz-Orzechowska, Ewelina; Latacz, Gniewomir; Wesolowska, Anna; Carrieri, Antonio; Handzlik, Jadwiga.
Afiliación
  • Czarnota-Lydka K; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, sw. Lazarza 15, 31-530, Krakow, Poland. Electronic address: kinga.czarnota@do
  • Sudol-Talaj S; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, sw. Lazarza 15, 31-530, Krakow, Poland. Electronic address: s.sudol@doctoral.
  • Kucwaj-Brysz K; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: katarzyna.kucwaj@uj.edu.pl.
  • Kurczab R; Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smetna 12, PL 31-343, Krakow, Poland. Electronic address: kurczab@if-pan.krakow.pl.
  • Satala G; Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smetna 12, PL 31-343, Krakow, Poland. Electronic address: satala@if-pan.krakow.pl.
  • de Candia M; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: modesto.decandia@uniba.it.
  • Samarelli F; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: francesco.samarelli@uniba.it.
  • Altomare CD; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: cosimodamiano.altomare@uniba.it.
  • Carocci A; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: alessia.carocci@uniba.it.
  • Barbarossa A; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: alexia.barbarossa@uniba.it.
  • Zeslawska E; Pedagogical University of Krakow, Institute of Biology and Earth Sciences, Podchorazych 2, PL 30-084, Krakow, Poland. Electronic address: ewa.zeslawska@up.krakow.pl.
  • Gluch-Lutwin M; Department of Pharmacobiology, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: monika.gluch-lutwin@uj.edu.pl.
  • Mordyl B; Department of Pharmacobiology, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: barbara.mordyl@uj.edu.pl.
  • Kubacka M; Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: monika.kubacka@uj.edu.pl.
  • Wilczynska-Zawal N; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: natalia.wilczynska@uj.edu.pl.
  • Jastrzebska-Wiesek M; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: m.jastrzebska-wiesek@uj.edu.pl.
  • Partyka A; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: annairena.partyka@uj.edu.pl.
  • Khan N; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, sw. Lazarza 15, 31-530, Krakow, Poland; Department of Pathophysiology, Jagiel
  • Wiecek M; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: malgorzata.wiecek@uj.edu.pl.
  • Nitek W; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, PL 30-387, Krakow, Poland. Electronic address: wojciech.nitek@uj.edu.pl.
  • Honkisz-Orzechowska E; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: ewelina.honkisz@uj.edu.pl.
  • Latacz G; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: gniewomir.latacz@uj.edu.pl.
  • Wesolowska A; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: a.wesolowska@uj.edu.pl.
  • Carrieri A; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: antonio.carrieri@uniba.it.
  • Handzlik J; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: j.handzlik@uj.edu.pl.
Eur J Med Chem ; 259: 115695, 2023 Nov 05.
Article en En | MEDLINE | ID: mdl-37567058
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calcógenos / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calcógenos / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article Pais de publicación: Francia