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Mechanism and antibacterial synergies of poly(Dabco-BBAC) nanoparticles against multi-drug resistant Pseudomonas aeruginosa isolates from human burns.
Ebadati, Arefeh; Oshaghi, Mojgan; Saeedi, Sara; Parsa, Parastoo; Mahabadi, Vahid Pirhajati; Karimi, Morteza; Hajiebrahimdehi, Atefeh Jahandideh; Hamblin, Michael R; Karimi, Mahdi.
Afiliación
  • Ebadati A; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran U
  • Oshaghi M; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. Electronic address: mobin255@gmail.com.
  • Saeedi S; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran U
  • Parsa P; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • Mahabadi VP; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Karimi M; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran; Karen Diagnostic Laboratory, Varamin, Iran; Sepid Diagnostic Laboratory, Varamin, Iran.
  • Hajiebrahimdehi AJ; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran U
  • Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa.
  • Karimi M; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran U
Bioorg Chem ; 140: 106718, 2023 11.
Article en En | MEDLINE | ID: mdl-37566942
Multi-drug resistant bacteria are a major problem in the treatment of infectious diseases, such as pneumonia, meningitis, or even coronavirus disease 2019 (COVID-19). Cationic nanopolymers are a new type of antimicrobial agent with high efficiency. We synthesized and characterized cationic polymer based on 1,4-diazabicyclo [2.2.2] octane (DABCO) and Bis (bromoacetyl)cystamine (BBAC), named poly (DABCO-BBAC) nanoparticles(NPs), and produced 150 nm diameter NPs. The antibacterial activity of poly (DABCO-BBAC) against eight multi drug resistant (MDR) Pseudomonas aeruginosa isolates from human burns, its possible synergistic effect with gentamicin, and the mechanism of action were examined. Poly(DABCO-BBAC) could effectively inhibit and kill bacterial strains at a very low concentration calculated by minimum inhibitory concentration (MIC) assay. Nevertheless, its synergism index with gentamicin showed an indifferent effect. Moreover, transmission electron microscopy and lipid peroxidation assays showed that poly (DABCO-BBAC) distorted and damaged the bacterial cell wall. These results suggest that the poly (DABCO-BBAC) could be an effective antibacterial agent for MDR clinical pathogens.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quemaduras / Nanopartículas / COVID-19 Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quemaduras / Nanopartículas / COVID-19 Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos