Subarachnoid administration of iohexol in cynomolgus monkeys.
Acta Radiol Diagn (Stockh)
; 27(3): 349-55, 1986.
Article
en En
| MEDLINE
| ID: mdl-3755859
A non-ionic diagnostic medium, iohexol, was administered by subarachnoid injection to groups of six cynomolgus monkeys and compared with the vehicle, physiologically normal saline, and/or saline of equal osmolality to determine its potential for increasing total protein and leucocyte levels in cerebrospinal fluid. Also investigated was the effect of repeated spinal taps not subsequently followed by the intrathecal injection of test or control articles. In the monkey, unlike man, low-level leucocyte counts were consistently observed following initial withdrawal of spinal fluid. Elevated leucocyte and total protein levels were observed in the present investigations one day to a week after intrathecal injection of radiopaque, vehicle or saline solution. Total protein returned to normal levels earlier than did leucocyte counts. However, repeated needle puncture alone was found to be sufficient to cause an elevation of leucocytes 3 to 4 times the baseline level, while inflammatory effects were observed histologically only when autopsy was performed soon after the final spinal tap.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Triyodobenzoicos
/
Medios de Contraste
/
Yodobenzoatos
Límite:
Animals
Idioma:
En
Revista:
Acta Radiol Diagn (Stockh)
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Suecia