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Oncological safety of nipple-sparing mastectomy after neoadjuvant chemotherapy: a systematic review.
Nissen, Leonardo; Soares, Isabela Chaves Monteiro; Lima, Rubens Silveira DE; Urban, Cicero DE Andrade; Rabinovich, Iris.
Afiliación
  • Nissen L; - Hospital de Clínicas da UFPR, Departamento de Tocoginecologia - Curitiba - PR - Brasil.
  • Soares ICM; - Centro de Doeças da Mama - CDM Curitiba, Mastologia - Curitiba - PR - Brasil.
  • Lima RS; - Centro de Doeças da Mama - CDM Curitiba, Mastologia - Curitiba - PR - Brasil.
  • Urban CA; - Centro de Doeças da Mama - CDM Curitiba, Mastologia - Curitiba - PR - Brasil.
  • Rabinovich I; - Hospital de Clínicas da UFPR, Departamento de Tocoginecologia - Curitiba - PR - Brasil.
Rev Col Bras Cir ; 50: e20233515, 2023.
Article en En, Pt | MEDLINE | ID: mdl-37556611
BACKGROUND: the use of nipple-sparing mastectomy (NSM) in local advanced breast cancer after neoadjuvant chemotherapy (NQT) is increasing, despite few studies on the subject. The aim of this systematic review was to determine the safety of NSM after neoadjuvant chemotherapy. METHODS: for this systematic review we searched MEDLINE; Cochrane; Scientific Electronic Library Online (SciELO); Embase and Scopus. A literature search of all original studies including randomized controlled trials, cohort studies and case-control studies comparing women undergoing NSM after neoadjuvant chemotherapy for breast cancer was undertaken. Outcomes were locoregional recurrence (LRR), nipple recurrence and distant recurrence (DR). Data analysis was undertaken to explore the safety of NSM after NQT. The quality of the evidence was assessed with the Cochrane risk of bias tool. This study is registered on PROSPERO, number CRD42021276778. FINDINGS: a total of 437 articles were identified. Four articles were included with 1466 patients all of which had a high to serious risk of overall bias. Local recurrence in the NSM after the NQT group ranged from zero to 9.8%. Nippleareolar complex (NAC) recurrence ranged from zero to 2.1%. The distant recurrence rate ranged from 6.5% to 16%. Due to the lack of pattern among the control groups, it was not possible to perform a meta-analysis. INTERPRETATION: this review provides information for decision making in performing NSM after NQT. Despite the low rates of local recurrence and patients should be counseled about limited oncological information.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans Idioma: En / Pt Revista: Rev Col Bras Cir Año: 2023 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans Idioma: En / Pt Revista: Rev Col Bras Cir Año: 2023 Tipo del documento: Article Pais de publicación: Brasil