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Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan.
Tickell, Kirkby D; Denno, Donna M; Saleem, Ali; Kazi, Zaubina; Singa, Benson O; Achieng, Catherine; Mutinda, Charles; Richardson, Barbra A; Ásbjörnsdóttir, Kristjana H; Hawes, Stephen E; Berkley, James A; Walson, Judd L.
Afiliación
  • Tickell KD; Department of Global Health, University of Washington, Seattle, WA, USA.
  • Denno DM; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
  • Saleem A; Department of Global Health, University of Washington, Seattle, WA, USA.
  • Kazi Z; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
  • Singa BO; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
  • Achieng C; Aga Khan University, Karachi, Pakistan.
  • Mutinda C; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
  • Richardson BA; Aga Khan University, Karachi, Pakistan.
  • Ásbjörnsdóttir KH; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
  • Hawes SE; Kenya Medical Research Institute, Nairobi, Kenya.
  • Berkley JA; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
  • Walson JL; Kenya Medical Research Institute, Nairobi, Kenya.
iScience ; 26(8): 107294, 2023 Aug 18.
Article en En | MEDLINE | ID: mdl-37554451
We aimed to establish if enteric permeability was associated with similar biological processes in children recovering from hospitalization and relatively healthy children in the community. Extreme gradient boosted models predicting the lactulose-rhamnose ratio (LRR), a biomarker of enteric permeability, using 7,500 plasma proteins and 34 fecal biomarkers of enteric infection among 89 hospitalized and 60 community children aged 2-23 months were built. The R2 values were calculated in test sets. The models performed better among community children (R2: 0.27 [min-max: 0.19, 0.53]) than hospitalized children (R2: 0.07 [min-max: 0.03, 0.11]). In the community, LRR was associated with biomarkers of humoral antimicrobial and cellular lipopolysaccharide responses and inversely associated with anti-inflammatory and innate immunological responses. Among hospitalized children, the selected biomarkers had few shared functions. This suggests enteric permeability among community children was associated with a host response to pathogens, but this association was not observed among hospitalized children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: IScience Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: IScience Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos