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Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage.
Zou, Shuaijun; Wang, Qianqian; He, Qian; Liu, Guoyan; Song, Juxingsi; Li, Jie; Wang, Fan; Huang, Yichao; Hu, Yanan; Zhou, Dayuan; Lv, Yongfei; Zhu, Yuanjie; Wang, Beilei; Zhang, Liming.
Afiliación
  • Zou S; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Wang Q; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • He Q; The Third Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
  • Liu G; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Song J; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Li J; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Wang F; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Huang Y; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Hu Y; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Zhou D; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Lv Y; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China.
  • Zhu Y; Department of Marine Biological Injury and Dermatology, Naval Special Medical Centre, Naval Medical University, Shanghai, 200052, China. 13918338960@126.com.
  • Wang B; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China. beileiwang@smmu.edu.cn.
  • Zhang L; Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Centre, Naval Medical University, Shanghai, 200433, China. lmzhang@smmu.edu.cn.
J Nanobiotechnology ; 21(1): 256, 2023 Aug 07.
Article en En | MEDLINE | ID: mdl-37550745
BACKGROUND: Organophosphate (OP)-induced delayed neurological damage is attributed to permanent neuropathological lesions caused by irreversible OP-neurocyte interactions, without potent brain-targeted etiological antidotes to date. The development of alternative therapies to achieve intracerebral OP detoxification is urgently needed. METHODS: We designed a brain-targeted nanoreactor by integrating enzyme immobilization and biomimetic membrane camouflaging protocols with careful characterization, and then examined its blood-brain barrier (BBB) permeability both in vitro and in vivo. Subsequently, the oxidative stress parameters, neuroinflammatory factors, apoptotic proteins and histopathological changes were measured and neurobehavioral tests were performed. RESULTS: The well-characterized nanoreactors exerted favourable BBB penetration capability both in vitro and in vivo, significantly inhibiting OP-induced intracerebral damage. At the cellular and tissue levels, nanoreactors obviously blocked oxidative stress, cellular apoptosis, inflammatory reactions and brain histopathological damage. Furthermore, nanoreactors radically prevented the occurrence of OP-induced delayed cognitive deficits and psychiatric abnormality. CONCLUSION: The nanoreactors significantly prevented the development of OP-induced delayed neurological damage, suggesting a potential brain-targeted etiological strategy to attenuate OP-related delayed neurological and neurobehavioral disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organofosfatos / Intoxicación por Organofosfatos Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organofosfatos / Intoxicación por Organofosfatos Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido