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Cardiopulmonary physiological effects of diuretic therapy in preterm infants with chronic pulmonary hypertension.
Zhu, Faith; Ibarra Rios, Daniel; Joye, Sebastien; Baczynski, Michelle; Rios, Danielle; Giesinger, Regan E; McNamara, Patrick J; Jain, Amish.
Afiliación
  • Zhu F; Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
  • Ibarra Rios D; Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
  • Joye S; Neonatology Department, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Baczynski M; Lausanne University Hospital, Lausanne, Switzerland.
  • Rios D; Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
  • Giesinger RE; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • McNamara PJ; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • Jain A; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
J Perinatol ; 43(10): 1288-1294, 2023 10.
Article en En | MEDLINE | ID: mdl-37550529
OBJECTIVE: Using targeted neonatal echocardiography (TNE) to examine cardiopulmonary physiological impact of diuretics in preterm infants with chronic pulmonary hypertension (cPH). STUDY DESIGN: Retrospective study comparing TNE indices pre- and ≤2 weeks (post) of initiating diuretic therapy in infants born <32 weeks gestational age with cPH. RESULTS: Twenty-seven neonates with mean gestational age, birthweight and interval between pre-post diuretic TNE of 27.0 ± 2.8 weeks, 859 ± 294 grams, and 7.8 ± 3.0 days respectively were studied. Diuretics was associated with improvement in pulmonary vascular resistance [pulmonary artery acceleration time (PAAT); 34.27(9.76) vs. 40.24(11.10)ms, p = 0.01), right ventricular (RV) ejection time:PAAT ratio [5.92(1.66) vs. 4.83(1.14), p < 0.01)], RV fractional area change [41.6(9.8) vs. 46.4(6.5%), p = 0.03)] and left ventricular myocardial performance index [0.55(0.09) vs. 0.41(0.23), p < 0.01)]. Post-treatment, frequency of bidirectional/right-to-left inter-atrial shunts decreased significantly (24% vs. 4%, p = 0.05). CONCLUSION: Primary diuretic treatment in neonates with cPH may result in improvement in PVR, RV and LV function and compliance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Hipertensión Pulmonar Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans / Infant / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Hipertensión Pulmonar Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans / Infant / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos