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Causes of death and treatment-related mortality in newly diagnosed childhood acute lymphoblastic leukemia treatment with Chinese Children's Cancer Group study ALL-2015.
Liu, Kangkang; Shao, Jingbo; Cai, Jiaoyang; Tang, Jingyan; Shen, Shuhong; Xu, Fengling; Ren, Yuanyuan; Zhang, Aijun; Tian, Xin; Lu, Xiaoqian; Hu, Shaoyan; Hu, Qun; Jiang, Hua; Zhou, Fen; Liang, Changda; Leung, Alex Wing Kwan; Zhai, Xiaowen; Li, Chunfu; Fang, Yongjun; Wang, Zhenling; Wen, Lu; Yang, Hui; Wang, Ningling; Jiang, Hui.
Afiliación
  • Liu K; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Shao J; Department of Hematology/Oncology, Children's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
  • Cai J; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University of School of Medicine, Shanghai, China.
  • Tang J; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University of School of Medicine, Shanghai, China.
  • Shen S; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University of School of Medicine, Shanghai, China.
  • Xu F; Department of Hematology/Oncology, Children's Hospital of Chongqing Medical University, Chongqing, China.
  • Ren Y; Department of Pediatrics, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
  • Zhang A; Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
  • Tian X; Department of Hematology/Oncology, Kunming Children's Hospital, Kunming, China.
  • Lu X; Department of Hematology/Oncology, West China Second Hospital of Sichuan University, Chengdu, China.
  • Hu S; Department of Hematology/Oncology, Children's Hospital of Soochow University, Suzhou, China.
  • Hu Q; Department of Pediatrics, Huazhong University of Science and Technology Tongji Medical College Tongji Hospital, Wuhan, China.
  • Jiang H; Department of Hematology/Oncology, Guangzhou Women and Children Health Care Center, Guangzhou, China.
  • Zhou F; Department of Pediatrics, Huazhong University of Science and Technology Tongji Medical College Union Hospital, Wuhan, China.
  • Liang C; Department of Hematology/Oncology, Jiangxi Provincial Children's Hospital, Nanchang, China.
  • Leung AWK; Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong Children's Hospital, Hong Kong, China.
  • Zhai X; Department of Hematology/Oncology, Children's Hospital of Fudan University, Shanghai, China.
  • Li C; Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Fang Y; Department of Hematology/Oncology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China.
  • Wang Z; Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, China.
  • Wen L; Department of Hematology/Oncology, Northwest Women's and Children's Hospital, Xi'an, China.
  • Yang H; Department of Pediatrics, Xiangya Hospital Central South University, Changsha, Hunan, China.
  • Wang N; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. zwnltt@126.com.
  • Jiang H; Department of Hematology/Oncology, Children's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China. jhui0111@126.com.
Ann Hematol ; 102(12): 3431-3444, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37550503
To investigate the possible risk factors for death at post-treatment in children with acute lymphoblastic leukemia (ALL). A multivariate competing risk analysis was performed to retrospectively analyze the data of children with ALL who died after treatment with CCCG-ALL-2015 in China and to determine the possible risk factors for death at post-treatment in children with ALL. Age at the first diagnosis of ≥10 years; final risk level of high-risk; D19 minimal residual disease (MRD) (≥0.01%) and D46 MRD (≥0.01%); genetic abnormalities, such as KMT2A-rearrangement, c-Myc rearrangement, and PDGFRB rearrangement; and the presence of CNS3 (all P values, <0.05) were identified as independent risk factors, whereas the risk level at the first diagnosis of low-risk (LR) and ETV6::RUNX1 positivity was considered as independent protective factors of death in children with ALL. Among the 471 cases of death, 45 cases were treated with CCCG-ALL-2015 only, and 163 (34.61%) were treatment-related, with 62.42% due to severe infections. 55.83% of treatment-related mortality (TRM) occurred in the early phase of treatment (induction phase). TRM has a significant impact on the overall survival of pediatric patients with ALL. Moreover, the CCCG-ALL-2015 regimen has a better safety profile for treating children with ALL, with rates close to those in developed countries (registration number: ChiCTR-IPR-14005706; date of registration: June 4, 2014).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Pueblos del Este de Asia Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Pueblos del Este de Asia Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania