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Characterization of oral candidiasis according to antiretroviral treatment status, immunological and virological profiles among HIV infected patients in two health facilities in Yaoundé-Cameroon: a cross-sectional and analytical study.
Fokam, Joseph; Nka, Alex Durand; Semengue, Ezechiel Ngoufack Jagni; Asso'o, Cynthia Kelly Essono; Gabisa, Jeremiah Efakika; Ka'e, Aude Christelle; Bouba, Yagai; Pabo, Willy; Geh, Buolikeze Kuoh Nji; Gouissi, Davy; Chenwi, Collins Ambe; Tchouaket, Michel Carlos Tommo; Abba, Aissatou; Takou, Désiré; Fainguem, Nadine; Kamgaing, Rachel Simo; Sosso, Samuel Martin; Abena, Marie Elvire Nokam; Ndjolo, Alexis.
Afiliación
  • Fokam J; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Nka AD; Faculty of Health Science, University of Buea, Buea, Cameroon.
  • Semengue ENJ; Ministry of Public Health, National HIV Drug Resistance Working Group, Yaoundé, Cameroon.
  • Asso'o CKE; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Gabisa JE; Faculty of Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
  • Ka'e AC; Faculty of Sciences and Technology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon.
  • Bouba Y; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Pabo W; Faculty of Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
  • Geh BKN; Faculty of Sciences and Technology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon.
  • Gouissi D; Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
  • Chenwi CA; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Tchouaket MCT; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Abba A; Faculty of Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
  • Takou D; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Fainguem N; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Kamgaing RS; Faculty of Science, University of Buea, Buea, Cameroon.
  • Sosso SM; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Abena MEN; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
  • Ndjolo A; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.
Pan Afr Med J ; 45: 33, 2023.
Article en En | MEDLINE | ID: mdl-37545607
Introduction: oral candidiasis in HIV-disease generally indicates immune incompetence both among antiretroviral treatment (ART) naive and experienced patients. To optimize oral healthcare among people living with HIV (PLHIV) in sub-Saharan Africa (SSA), we sought to evaluate the type and distribution of oral candidiasis with respect to ART-profile and immuno-virological parameters among PLHIV in the Cameroonian context. Methods: a cross-sectional study was conducted among 163 patients (51 ART-naïve and 112 ART-experienced) residing in Yaoundé, Cameroon, from February through May 2019. Oral candidiasis was assessed, while viral load (VL) and CD4-count were measured on Abbott m2000rt and Cy-flow counter platforms, respectively. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) v.21 with p<0.05 considered statistically significant. Results: in all, 18 cases of two forms of oral candidiasis were identified (13 erythematous and 5 pseudomembranous), with the majority, 27.7% (11/51), observed among ART-naïve patients against 6.3% (7/112) in ART-experienced (p=0.006). With respect to immuno-virological profile, 77.8% (14/18) and 22.2% (4/18) of cases were identified among participants with CD4<200 cells/mm3 and CD4>200 cells/mm3, respectively (p<0.0001). In the light of viral load, the occurrence of oral candidiasis was largely observed among subjects with VL≥1000 copies/ml, 83.3% (15/18), against 16.7% (3/18), with VL<1000 copies/ml, irrespective of the candidiasis form (p<0.0001). Conclusion: among PLHIV, erythematous and pseudomembranous candidiasis are commonly found in the absence of ART, driven by immunodeficiency and active viral replication. In spite of the protective role of ART, PLHIV experiencing immuno-virological failure should be referred for management of oral candidiasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidiasis / Candidiasis Bucal / Infecciones por VIH / Fármacos Anti-VIH Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Pan Afr Med J Año: 2023 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Uganda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidiasis / Candidiasis Bucal / Infecciones por VIH / Fármacos Anti-VIH Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Pan Afr Med J Año: 2023 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Uganda