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Effect of corticosubcortical iron deposition on dysfunction in CADASIL is mediated by white matter microstructural damage.
Jia, Xiuqin; Li, Yingying; Ying, Yunqing; Jia, Xuejia; Tang, Weijun; Bian, Yueyan; Zhang, Jiajia; Wang, Danny J J; Cheng, Xin; Yang, Qi.
Afiliación
  • Jia X; Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing 100020, China.
  • Li Y; Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
  • Ying Y; Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
  • Jia X; Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
  • Tang W; Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
  • Bian Y; Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
  • Zhang J; Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
  • Wang DJJ; Laboratory of FMRI Technology (LOFT), USC Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, United States.
  • Cheng X; Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: chengxin@fudan.edu.cn.
  • Yang Q; Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing 100020, China. Electronic address: yangyangqiqi@gmail.com.
Neuroimage Clin ; 39: 103485, 2023.
Article en En | MEDLINE | ID: mdl-37542975
Iron dysregulation may attenuate cognitive performance in patients with CADASIL. However, the underlying pathophysiological mechanisms remain incompletely understood. Whether white matter microstructural changes mediate these processes is largely unclear. In the present study, 30 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients were confirmed via genetic analysis and 30 sex- and age-matched healthy controls underwent multimodal MRI examinations and neuropsychological assessments. Quantitative susceptibility mapping and peak width of skeletonized mean diffusivity (PSMD) were analyzed. Mediation effect analysis was performed to explore the interrelationship between iron deposition, white matter microstructural changes and cognitive deficits in CADASIL. Cognitive deterioration was most affected in memory and executive function, followed by attention and working memory in CADASIL. Excessive iron in the temporal-precuneus pathway and deep gray matter specific to CADASIL were identified. Mediation analysis further revealed that PSMD mediated the relationship between iron concentration and cognitive profile in CADASIL. The present findings provide a new perspective on iron deposition in the corticosubcortical circuit and its contribution to disease-related selective cognitive decline, in which iron concentration may affect cognition by white matter microstructural changes in CADASIL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: CADASIL / Sustancia Blanca Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: CADASIL / Sustancia Blanca Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos