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Metabolomic profiling of a neurodegenerative retina following optic nerve transection.
Zhu, Jun-Ya; Ni, Xi-Sen; Han, Xiao-Yan; Liu, Sha; Ji, Yu-Ke; Yao, Jin; Yan, Biao.
Afiliación
  • Zhu JY; Department of Ophthalmology and Optometry, The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
  • Ni XS; Department of Ophthalmology and Optometry, The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
  • Han XY; Eye Institute and Department of Ophthalmology, Eye and Ear, Nose and Throat Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200030, P.R. China.
  • Liu S; Department of Ophthalmology and Optometry, The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
  • Ji YK; Department of Ophthalmology and Optometry, The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
  • Yao J; Department of Ophthalmology and Optometry, The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
  • Yan B; Eye Institute and Department of Ophthalmology, Eye and Ear, Nose and Throat Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200030, P.R. China.
Mol Med Rep ; 28(3)2023 09.
Article en En | MEDLINE | ID: mdl-37539744
The degeneration of retinal ganglion cells (RGCs) often causes irreversible vision impairment. Prevention of RGC degeneration can prevent or delay the deterioration of visual function. The present study aimed to investigate retinal metabolic profiles following optic nerve transection (ONT) injury and identify the potential metabolic targets for the prevention of RGC degeneration. Retinal samples were dissected from ONT group and non­ONT group. The untargeted metabolomics were carried out using liquid chromatography­tandem mass spectrometry. The involved pathways and biomarkers were analyzed using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and MetaboAnalyst 5.0. In the ONT group, 689 disparate metabolites were detected, including lipids and lipid­like molecules. A total of 122 metabolites were successfully annotated and enriched in 50 KEGG pathways. Among them, 'sphingolipid metabolism' and 'primary bile acid biosynthesis' were identified involved in RGC degeneration. A total of five metabolites were selected as the candidate biomarkers for detecting RGC degeneration with an AUC value of 1. The present study revealed that lipid­related metabolism was involved in the pathogenesis of retinal neurodegeneration. Taurine, taurochenodesoxycholic acid, taurocholic acid (TCA), sphingosine, and galabiosylceramide are shown as the promising biomarkers for the diagnosis of RGC degeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos del Nervio Óptico Límite: Humans Idioma: En Revista: Mol Med Rep Año: 2023 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos del Nervio Óptico Límite: Humans Idioma: En Revista: Mol Med Rep Año: 2023 Tipo del documento: Article Pais de publicación: Grecia