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Pulmonary embolism post-Covid-19 infection: physiopathological mechanisms and vascular damage biomarkers.
Petramala, Luigi; Sarlo, Francesca; Servello, Adriana; Baroni, Silvia; Suppa, Marianna; Circosta, Francesco; Galardo, Gioacchino; Gandini, Orietta; Marino, Luca; Cavallaro, Giuseppe; Iannucci, Gino; Concistrè, Antonio; Letizia, Claudio.
Afiliación
  • Petramala L; Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Sarlo F; UOC Chimica, Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Rome, Italy.
  • Servello A; Emergency Medicine Unit, Department of Emergency-Acceptance, Critical Areas and Trauma, Policlinico "Umberto I", Rome, Italy.
  • Baroni S; Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Suppa M; UOC Chimica, Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Rome, Italy.
  • Circosta F; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
  • Galardo G; UOC Chimica, Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Rome, Italy.
  • Gandini O; Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Marino L; UOC Chimica, Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Rome, Italy. luca.marino@uniroma1.it.
  • Cavallaro G; Department of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, Rome, Italy. luca.marino@uniroma1.it.
  • Iannucci G; Department of Surgery Pietro Valdoni, Sapienza" University of Rome, Rome, Italy.
  • Concistrè A; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
  • Letizia C; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Clin Exp Med ; 23(8): 4871-4880, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37537404
Covid-19 infection is characterized by several acute complications, as well long-term sequelae, mostly sustained by endothelial dysfunction; several studies show that complications as pulmonary embolism (PE) are described both in the acute phase and after negativization. Aim of research was to evaluate anthropometric, bio-humoral, instrumental parameters in a group of patients affected by PE after recent Covid-19 infection compared to PE patients without previous Covid-19 infection. We enrolled 72 consecutive patients (35M, 37F) with acute PE, distinguished in relation to previous acute Covid-19 infection: 54 pts without previous acute Covid-19 infection and 18 pts with previous Covid-19 infection within negativity at least 2 months before PE diagnosis; 44 healthy subjects (21M, 23F) were recruited as control group. Patients who had previously developed Covid-19 needed hospitalization in high percentage (84%); this group showed significantly higher prevalence of diabetes mellitus than Covid-19-free PE patients, reduced serum levels of C-reactive protein, sST2 and PESI score. In post-Covid-19 PE group, we observed higher mean IMPROVE risk score, whereas in Covid-19-free group lower P/F ratio, higher radiological severity, and worse PESI score and severity index. Covid-19 infection affects not just the lung parenchyma but also other organs; endothelial damage plays pivotal role in long-term alterations; in high thrombotic risk group (recent hospitalization due to acute Covid-19 infection), we have described thrombotic complications characterized by persistent prothrombotic state after recovery, highlighted by well-known markers as PCR and D-Dimer as well as novel vascular marker (sST2).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embolia Pulmonar / COVID-19 Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Exp Med Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embolia Pulmonar / COVID-19 Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Exp Med Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia