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Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Brehová, Petra; Reznícková, Eva; Skach, Krystof; Jorda, Radek; Dejmek, Milan; Vojácková, Veronika; Sála, Michal; Kovalová, Markéta; Dracínský, Martin; Dolníková, Alexandra; Strmen, Timotej; Kinnertová, Monika; Chalupský, Karel; Dvoráková, Alexandra; Gucký, Tomás; Mertlíková Kaiserová, Helena; Klener, Pavel; Nencka, Radim; Krystof, Vladimír.
Afiliación
  • Brehová P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Reznícková E; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
  • Skach K; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Jorda R; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
  • Dejmek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Vojácková V; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
  • Sála M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Kovalová M; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
  • Dracínský M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Dolníková A; Institute of Pathological Physiology, First Faculty of Medicine, Charles University, 12108 Prague, Czech Republic.
  • Strmen T; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Kinnertová M; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
  • Chalupský K; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Dvoráková A; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Gucký T; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
  • Mertlíková Kaiserová H; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Klener P; Institute of Pathological Physiology, First Faculty of Medicine, Charles University, 12108 Prague, Czech Republic.
  • Nencka R; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 16000 Prague, Czech Republic.
  • Krystof V; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
J Med Chem ; 66(16): 11133-11157, 2023 08 24.
Article en En | MEDLINE | ID: mdl-37535845
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridazinas / Leucemia Mieloide Aguda / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridazinas / Leucemia Mieloide Aguda / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos