Weak-hyperactive hippocampal CA1 neurons in the prodromal stage of Alzheimer's disease in hybrid App<sup>NL-G-F/NL-G-F</sup> × Thy1-GCaMP6s<sup>+/-</sup> mice suggest disrupted plasticity.

Inayat, Samsoon; McAllister, Brendan B; Chang, HaoRan; Lacoursiere, Sean G; Whishaw, Ian Q; Sutherland, Robert J; Mohajerani, Majid H

Weak-hyperactive hippocampal CA1 neurons in the prodromal stage of Alzheimer's disease in hybrid App^{NL-G-F/NL-G-F} × Thy1-GCaMP6s^+/- mice suggest disrupted plasticity.

Inayat, Samsoon; McAllister, Brendan B; Chang, HaoRan; Lacoursiere, Sean G; Whishaw, Ian Q; Sutherland, Robert J; Mohajerani, Majid H.

Afiliación

Inayat S; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada. Electronic address: sam.inayat@unlv.edu.
McAllister BB; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Chang H; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Lacoursiere SG; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Whishaw IQ; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Sutherland RJ; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Mohajerani MH; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada. Electronic address: mohajerani@uleth.ca.

Neurobiol Aging ; 130: 154-171, 2023 10.

Article en En | MEDLINE | ID: mdl-37531809

Asunto(s)

Enfermedad de Alzheimer; Disfunción Cognitiva; Animales; Ratones; Enfermedad de Alzheimer/metabolismo; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Disfunción Cognitiva/patología; Modelos Animales de Enfermedad; Hipocampo/patología; Ratones Transgénicos; Neuronas/metabolismo; Síntomas Prodrómicos

Palabras clave

Air induced running task; Alzheimer's disease; App(NL-G-F); Calcium imaging; Morris water task; Thy1-GCaMP6s

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

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