Modulation of a conformational ensemble by a small molecule that inhibits key protein-protein interactions involved in cell adhesion.

Senoo, Akinobu; Nagatoishi, Satoru; Kuroda, Daisuke; Ito, Sho; Ueno, Go; Caaveiro, Jose M M; Tsumoto, Kouhei

Senoo, Akinobu; Nagatoishi, Satoru; Kuroda, Daisuke; Ito, Sho; Ueno, Go; Caaveiro, Jose M M; Tsumoto, Kouhei.

Afiliación

Senoo A; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Nagatoishi S; Department of Global Healthcare, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Kuroda D; Medical Device Development and Regulation Research Center, School of Engineering, The University of Tokyo, Tokyo, Japan.
Ito S; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Ueno G; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Caaveiro JMM; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Tsumoto K; Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan.

Protein Sci ; 32(9): e4744, 2023 09.

Article en En | MEDLINE | ID: mdl-37531208

Asunto(s)

Cadherinas; Simulación de Dinámica Molecular; Adhesión Celular; Conformación Proteica; Cadherinas/metabolismo; Unión Proteica

Palabras clave

cadherin; conformational change; inhibition mechanism; protein-protein interaction; small molecule

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Simulación de Dinámica Molecular Idioma: En Revista: Protein Sci Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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