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Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp.
Chen, Rachel; Minns, Scott A; Kalaitzis, John A; Butler, Mark S; Rosin, Maira; Vuong, Daniel; Lean, Soo Sum; Chooi, Yit-Heng; Lacey, Ernest; Piggott, Andrew M.
Afiliación
  • Chen R; Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.
  • Minns SA; Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.
  • Kalaitzis JA; School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
  • Butler MS; MSBChem Consulting, New Farm, QLD 4005, Australia.
  • Rosin M; Department of Molecular and Applied Microbiology, Jena Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena D-07745, Germany.
  • Vuong D; School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
  • Lean SS; School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia.
  • Chooi YH; School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia.
  • Lacey E; Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.
  • Piggott AM; School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
J Nat Prod ; 86(8): 2054-2058, 2023 08 25.
Article en En | MEDLINE | ID: mdl-37526586
Turonicin A (1) was isolated from Streptomyces sp. MST-123921, which was recovered from soil collected on the banks of the Turon River in New South Wales, Australia. Turonicin A (1) is an amphoteric linear polyene polyketide featuring independent pentaene and tetraenone chromophores and is structurally related to linearmycins A-C (2-4). The structure of 1 was determined by detailed spectroscopic analysis and comparison to literature data. Bioinformatic analysis of the linearmycin biosynthetic gene cluster also allowed the previously unresolved absolute stereostructures of 2-4 to be elucidated. Turonicin A (1) exhibited very potent activity against the fungi Candida albicans (MIC 0.0031 µg/mL, 2.7 nM) and Saccharomyces cerevisiae (MIC 0.0008 µg/mL, 0.7 nM), moderate activity against the bacteria Bacillus subtilis (MIC 0.097 µg/mL, 85 nM) and Staphylococcus aureus (MIC 0.39 µg/mL, 340 nM), and no cytotoxicity against human fibroblasts, making it an attractive candidate for further development as a potential next-generation antibiotic scaffold.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Policétidos Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: J Nat Prod Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Policétidos Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: J Nat Prod Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos