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Changes in salivary biomarkers of stress, inflammation, redox status, and muscle damage due to Streptococcus suis infection in pigs.
López-Martínez, María José; Ornelas, Mario Andre S; Amarie, Roxana Elena; Manzanilla, Edgar Garcia; Martínez-Subiela, Silvia; Tecles, Fernando; Tvarijonaviciute, Asta; Escribano, Damián; González-Bulnes, Antonio; Cerón, José Joaquín; López-Arjona, Marina; Muñoz-Prieto, Alberto.
Afiliación
  • López-Martínez MJ; Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence 'Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, 30100, Spain.
  • Ornelas MAS; Pig Development Department, The Irish Food and Agriculture Authority, Teagasc, Moorepark, Fermoy, Co Cork, P61 C996, Ireland.
  • Amarie RE; School of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland.
  • Manzanilla EG; Department of Agriculture, Food, and Environment, University of Pisa, Pisa, Italy.
  • Martínez-Subiela S; Pig Development Department, The Irish Food and Agriculture Authority, Teagasc, Moorepark, Fermoy, Co Cork, P61 C996, Ireland.
  • Tecles F; School of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland.
  • Tvarijonaviciute A; Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence 'Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, 30100, Spain.
  • Escribano D; Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence 'Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, 30100, Spain.
  • González-Bulnes A; Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence 'Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, 30100, Spain.
  • Cerón JJ; Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence 'Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, 30100, Spain.
  • López-Arjona M; Departamento de Producción y Sanidad Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, Valencia, 46115, Spain.
  • Muñoz-Prieto A; Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence 'Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, 30100, Spain.
BMC Vet Res ; 19(1): 100, 2023 Jul 31.
Article en En | MEDLINE | ID: mdl-37525237
BACKGROUND: Streptococcus suis (S. suis) is a Gram-positive bacteria that infects pigs causing meningitis, arthritis, pneumonia, or endocarditis. This increases the mortality in pig farms deriving in severe economic losses. The use of saliva as a diagnostic fluid has various advantages compared to blood, especially in pigs. In this study, it was hypothesized that saliva could reflect changes in different biomarkers related to stress, inflammation, redox status, and muscle damage in pigs with S. suis infection and that changes in these biomarkers could be related to the severity of the disease. RESULTS: A total of 56 growing pigs from a farm were selected as infected pigs (n = 28) and healthy pigs (n = 28). Results showed increases in biomarkers related to stress (alpha-amylase and oxytocin), inflammation (haptoglobin, inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), total protein, S100A8-A9 and S100A12), redox status (advanced oxidation protein producs (AOPP)) and muscle damage (creatine kinase (CK), CK-MB, troponin I, lactate, aspartate aminotransferase, and lactate dehydrogenase). An increase in adenosine deaminase (ADA), procalcitonin, and aldolase in infected animals were also observed, as previously described. The grade of severity of the disease indicated a significant positive correlation with total protein concentrations, aspartate aminotransferase, aldolase, and AOPP. CONCLUSIONS: This report revealed that S. suis infection caused variations in analytes related to stress, inflammation, redox status, and muscle damage in the saliva of pigs and these can be considered potential biomarkers for this disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Enfermedades de los Porcinos / Streptococcus suis Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Enfermedades de los Porcinos / Streptococcus suis Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido