Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma.

Yang, Yemei; Ma, Shengfang; Ye, Zi; Zheng, Yushi; Zheng, Zhenjiong; Liu, Xiongshan; Zhou, Xianyi

Yang, Yemei; Ma, Shengfang; Ye, Zi; Zheng, Yushi; Zheng, Zhenjiong; Liu, Xiongshan; Zhou, Xianyi.

Afiliación

Yang Y; Department of Dermatology and Venerology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, P. R. China.
Ma S; Department of Dermatology, Baoshihua Hospital of Gansu Province, Lanzhou, P. R. China.
Ye Z; College of Information and Sciences, The Pennsylvania State University, University of Pennsylvania, Philadelphia, USA.
Zheng Y; Department of Dermatology and Venerology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, P. R. China.
Zheng Z; Department of Dermatology and Venerology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, P. R. China.
Liu X; Department of Dermatology and Venerology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, P. R. China.
Zhou X; Department of Dermatology and Venerology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, P. R. China.

Epigenetics ; 18(1): 2239607, 2023 12.

Article en En | MEDLINE | ID: mdl-37523636

Asunto(s)

Melanoma; Proteínas Proto-Oncogénicas c-akt; Ratones; Animales; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteínas de Choque Térmico/genética; Proteínas de Choque Térmico/metabolismo; Fosfatidilinositol 3-Quinasas/genética; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Serina-Treonina Quinasas/metabolismo; Proteínas Adaptadoras Transductoras de Señales/genética; Proteínas Adaptadoras Transductoras de Señales/metabolismo; Proteínas Reguladoras de la Apoptosis/genética; Metilación de ADN; Chaperonas Moleculares/genética; Chaperonas Moleculares/metabolismo; Apoptosis; Melanoma/genética; Serina-Treonina Quinasas TOR/genética; Serina-Treonina Quinasas TOR/metabolismo; Metiltransferasas/genética; ADN/metabolismo; Autofagia/genética

Palabras clave

Apoptosis; Autophagy; Bcl2-associated athanogene 3; DNA methyltransferase 1; Heat shock protein B8; Melanoma; PI3K/AKT/mTOR pathway

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-akt / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Epigenetics Asunto de la revista: GENETICA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

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