Your browser doesn't support javascript.
loading
Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review.
Bian, Jialu; Zhao, Jinxia; Zhao, Yinyu; Hao, Xu; He, Shiyu; Li, Yuanyuan; Huang, Lin.
Afiliación
  • Bian J; Department of Pharmacy, People's Hospital of Peking University, Beijing, China.
  • Zhao J; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Science, Peking University, Beijing, China.
  • Zhao Y; Department of Pharmacy, People's Hospital of Peking University, Beijing, China.
  • Hao X; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Science, Peking University, Beijing, China.
  • He S; Department of Pharmacy, People's Hospital of Peking University, Beijing, China.
  • Li Y; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Science, Peking University, Beijing, China.
  • Huang L; Department of Pharmacy, People's Hospital of Peking University, Beijing, China.
Environ Mol Mutagen ; 64(7): 401-415, 2023 08.
Article en En | MEDLINE | ID: mdl-37522536
Individual differences in drug response have always existed in clinical treatment. Many non-genetic factors show non-negligible impacts on personalized medicine. Emerging studies have demonstrated epigenetic could connect non-genetic factors and individual treatment differences. We used systematic retrieval methods and reviewed studies that showed individual factors' impact on DNA methylation of drug metabolism genes. In total, 68 studies were included, and half (n = 36) were cohort studies. Six aspects of individual factors were summarized from the perspective of personalized medicine: parental exposure, environmental pollutants exposure, obesity and diet, drugs, gender and others. The most research (n = 11) focused on ABCG1 methylation. The majority of studies showed non-genetic factors could result in a significant DNA methylation alteration in drug metabolism genes, which subsequently affects the pharmacokinetic processes. However, the underlying mechanism remained unknown. Finally, some viewpoints were presented for future research.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética Tipo de estudio: Observational_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Environ Mol Mutagen Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética Tipo de estudio: Observational_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Environ Mol Mutagen Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos