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May Bradykinesia Features Aid in Distinguishing Parkinson's Disease, Essential Tremor, And Healthy Elderly Individuals?
Paparella, Giulia; Cannavacciuolo, Antonio; Angelini, Luca; Costa, Davide; Birreci, Daniele; Alunni Fegatelli, Danilo; Guerra, Andrea; Berardelli, Alfredo; Bologna, Matteo.
Afiliación
  • Paparella G; IRCCS Neuromed, Pozzilli, Italy.
  • Cannavacciuolo A; Department of Human Neurosciences, Sapienza University of Rome, Italy.
  • Angelini L; IRCCS Neuromed, Pozzilli, Italy.
  • Costa D; Department of Human Neurosciences, Sapienza University of Rome, Italy.
  • Birreci D; Department of Human Neurosciences, Sapienza University of Rome, Italy.
  • Alunni Fegatelli D; Department of Human Neurosciences, Sapienza University of Rome, Italy.
  • Guerra A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome,Italy.
  • Berardelli A; Parkinson and Movement Disorders Unit, Study Center on Neurodegeneration (CESNE), University of Padua, Padua, Italy.
  • Bologna M; IRCCS Neuromed, Pozzilli, Italy.
J Parkinsons Dis ; 13(6): 1047-1060, 2023.
Article en En | MEDLINE | ID: mdl-37522221
BACKGROUND: Bradykinesia is the hallmark feature of Parkinson's disease (PD); however, it can manifest in other conditions, including essential tremor (ET), and in healthy elderly individuals. OBJECTIVE: Here we assessed whether bradykinesia features aid in distinguishing PD, ET, and healthy elderly individuals. METHODS: We conducted simultaneous video and kinematic recordings of finger tapping in 44 PD patients, 69 ET patients, and 77 healthy elderly individuals. Videos were evaluated blindly by expert neurologists. Kinematic recordings were blindly analyzed. We calculated the inter-raters agreement and compared data among groups. Density plots assessed the overlapping in the distribution of kinematic data. Regression analyses and receiver operating characteristic curves determined how the kinematics influenced the likelihood of belonging to a clinical score category and diagnostic group. RESULTS: The inter-rater agreement was fair (Fleiss K = 0.32). Rater found the highest clinical scores in PD, and higher scores in ET than healthy elderly individuals (p < 0.001). In regard to kinematic analysis, the groups showed variations in movement velocity, with PD presenting the slowest values and ET displaying less velocity than healthy elderly individuals (all ps < 0.001). Additionally, PD patients showed irregular rhythm and sequence effect. However, kinematic data significantly overlapped. Regression analyses showed that kinematic analysis had high specificity in differentiating between PD and healthy elderly individuals. Nonetheless, accuracy decreased when evaluating subjects with intermediate kinematic values, i.e., ET patients. CONCLUSION: Despite a considerable degree of overlap, bradykinesia features vary to some extent in PD, ET, and healthy elderly individuals. Our findings have implications for defining bradykinesia and categorizing patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Temblor Esencial Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Aged / Humans Idioma: En Revista: J Parkinsons Dis Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Temblor Esencial Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Aged / Humans Idioma: En Revista: J Parkinsons Dis Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos