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Correlation of Peripheral Chimeric Antigen Receptor T-cell (CAR-T Cell) mRNA Expression Levels with Toxicities and Outcomes in Patients with Diffuse Large B-cell Lymphoma
Messerli, Christian; Wiedemann, Gertrud; Porret, Naomi; Nagler, Michael; Seipel, Katja; Jeker, Barbara; Novak, Urban; Zeerleder, Sacha; Bacher, Ulrike; Pabst, Thomas.
Afiliación
  • Messerli C; University Hospital and University of Bern, Department of Medical Oncology, Bern, Switzerland
  • Wiedemann G; University Hospital and University of Bern, Department of Hematology and Central Hematology Laboratory, Bern, Switzerland
  • Porret N; University Hospital and University of Bern, Department of Hematology and Central Hematology Laboratory, Bern, Switzerland
  • Nagler M; University Institute of Clinical Chemistry, University Hospital and University of Bern, Bern, Switzerland
  • Seipel K; University of Bern, Department for Biomedical Research, Bern, Switzerland
  • Jeker B; University Hospital and University of Bern, Department of Medical Oncology, Bern, Switzerland
  • Novak U; University Hospital and University of Bern, Department of Medical Oncology, Bern, Switzerland
  • Zeerleder S; University Hospital and University of Bern, Department of Hematology and Central Hematology Laboratory, Bern, Switzerland
  • Bacher U; University Hospital and University of Bern, Department of Hematology and Central Hematology Laboratory, Bern, Switzerland
  • Pabst T; University Hospital and University of Bern, Department of Medical Oncology, Bern, Switzerland
Turk J Haematol ; 40(3): 187-196, 2023 08 31.
Article en En | MEDLINE | ID: mdl-37519105
Cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are significant complications in patients with relapsed/refractory diffuse large B-cell lymphoma undergoing chimeric antigen receptor T-cell (CAR-T cell) therapy. However, it remains unclear whether CAR-T cell expression itself is clinically relevant. We assessed CAR-T cell mRNA expression and DNA concentration by digital droplet PCR in peripheral blood from 14 sequential CAR-T cell recipients. Patients were grouped according to CAR-T cell peak expression. Patients with high CAR-T cell peak expression (8 patients; 57%) had higher rates of ICANS (p=0.0308) and intensive care unit admission (p=0.0404), longer durations of hospitalization (p=0.0077), and, although not statistically significant, a higher rate of CRS (p=0.0778). There was a correlation of CAR-T cell mRNA expression with DNA concentration, but CAR-T cell expression levels failed to correlate to response or survival. Our data suggest that higher CAR-T cell peak mRNA expression is associated with increased risk for ICANS and possibly CRS, requiring further investigation in larger studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Receptores Quiméricos de Antígenos Límite: Humans Idioma: En Revista: Turk J Haematol Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Turquía
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Receptores Quiméricos de Antígenos Límite: Humans Idioma: En Revista: Turk J Haematol Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Turquía