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Plasma Neurofilament Light Chain Is Elevated after Transcatheter Aortic Valve Implantation.
Sjölin, Karl; Christersson, Christina; James, Stefan; Lindbäck, Johan; Åsberg, Signild; Burman, Joachim.
Afiliación
  • Sjölin K; Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.
  • Christersson C; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
  • James S; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
  • Lindbäck J; Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.
  • Åsberg S; Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.
  • Burman J; Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.
Cardiology ; 148(5): 478-484, 2023.
Article en En | MEDLINE | ID: mdl-37517390
INTRODUCTION: Transcatheter aortic valve implantation (TAVI) is associated with a high incidence of new silent brain infarcts (SBIs) on postprocedural neuroimaging. A venous blood sample reflecting neuronal damage following TAVI could help identify patients with potential SBIs. We aimed to investigate if a biochemical marker of neuronal injury, neurofilament light chain (NFL), is elevated after TAVI. METHODS: In this observational study, NFL was measured in plasma from 31 patients before and after TAVI. Multivariable regression analysis was performed to investigate any effect of clinical- and procedure-related factors on differences in NFL levels before and after TAVI. RESULTS: Samples were collected 41 (14-81) days before and 44 (35-59) days after TAVI, median (interquartile range). Median age was 81 (77-84) years, and 35% were female. No patient had any overt procedure-related neurological complications. The geometric mean (95% confidence interval) of the NFL concentration was 30 (25-36) pg/mL before TAVI and 48 (39-61) pg/mL, after TAVI, p <0.001. None of the included variables in the multiple linear regression model were statistically significantly associated with the difference in levels before and after TAVI. CONCLUSIONS: NFL levels in plasma were higher after TAVI as compared with levels before, with a mean increase of 60% (18 pg/mL). Further studies including neuroimaging and cognitive outcomes are needed to understand the potential value of measuring NFL in relation to TAVI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estenosis de la Válvula Aórtica / Proteínas de Neurofilamentos / Infarto Encefálico / Reemplazo de la Válvula Aórtica Transcatéter Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 / Female / Humans / Male Idioma: En Revista: Cardiology Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estenosis de la Válvula Aórtica / Proteínas de Neurofilamentos / Infarto Encefálico / Reemplazo de la Válvula Aórtica Transcatéter Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 / Female / Humans / Male Idioma: En Revista: Cardiology Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza