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Are high avidity antibodies to Plasmodium falciparum antigens preferentially transferred across the placenta of premature and term babies?
Kayatani, Alexander K K; Bobbili, Naveen; Megnekou, Rosette; Matsunaga, Masako; Leke, Rose F G; Taylor, Diane Wallace.
Afiliación
  • Kayatani AKK; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Bioscience Building, Room 320, Honolulu, HI, 96813, USA. Electronic address: Alexander.K.Kayatani.mil@mail.mil.
  • Bobbili N; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Bioscience Building, Room 320, Honolulu, HI, 96813, USA. Electronic address: bobbili@hawaii.edu.
  • Megnekou R; The Biotechnology Center, University of Yaoundé 1, BP 3851, Messa, Yaoundé, Cameroon. Electronic address: megnekor@yahoo.fr.
  • Matsunaga M; Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Medical Education Building, Room 411, Honolulu, HI, 96813, USA. Electronic address: mmatsuna@hawaii.edu.
  • Leke RFG; The Biotechnology Center, University of Yaoundé 1, BP 3851, Messa, Yaoundé, Cameroon. Electronic address: roseleke@yahoo.com.
  • Taylor DW; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Bioscience Building, Room 320, Honolulu, HI, 96813, USA. Electronic address: dwtaylor@hawaii.edu.
Placenta ; 140: 11-19, 2023 09 07.
Article en En | MEDLINE | ID: mdl-37515848
INTRODUCTION: Transplacental transport of maternal IgG via the neonatal Fc receptor (FcRn) provides babies with passive immunity. Several factors are reported to influence transport, including the avidity of antibodies (Abs) for their cognate antigens. Unfortunately, information on the role of antibody (Ab) avidity is limited. This study investigated if i) antibodies (Abs) with high avidity for 6 Plasmodium falciparum antigens and tetanus toxoid (TTx) were preferentially transferred to premature and term Cameroonian babies and ii) if Ab avidity was increased in babies whose mothers had placental malaria (PM), implicating the involvement of immune complexes. METHODS: Total IgG (mg/ml) and Abs to malarial antigens (AMA1, EBA-175, MSP1-42, MSP2, MSP3, DBL5 of VAR2CSA) and TTx were measured in paired mother-cord samples obtained from premature and term deliveries in Cameroon. Half the women had PM at delivery. Avidity Indices (AIs) were determined by treating antigen-bound-Abs with different molar concentrations of NH4SCN and calculating 50% endpoints. RESULTS: Total IgG and antigen-specific Abs increased in cord blood with gestational age; however, AIs did not. AIs in paired maternal-cord blood samples were strongly associated for all antigens (r = 0.77-0.96). However, no significant different in AIs was found between paired mother-cord blood samples for any of the antigens (p values > 0.05). Similarly, Ab avidity was not increased in cord blood of babies whose mothers had PM or hypergammaglobulinemia. DISCUSSION: Overall, there was no evidence that higher avidity Abs to any of the malarial antigens or TTx were preferentially transferred to Cameroonian babies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria Falciparum / Nacimiento Prematuro Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Placenta Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malaria Falciparum / Nacimiento Prematuro Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Placenta Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos